A first synthesis of sulfonic acid analogues of N-acetylneuraminic acid

Zoltán B. Szabó, A. Borbás, István Bajza, A. Lipták, S. Antus

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Sulfonic acid analogues of N-acetylneuraminic are synthesized from 1-thio-l-fucoside derivatives with the introduction of an azido group at C-4 of the fucose moiety and carbanionic addition onto fully protected lactones. The analogues in the form of methyl glycosides are subjected to a neuraminidase inhibition assay.

Original languageEnglish
Pages (from-to)1196-1198
Number of pages3
JournalTetrahedron Letters
Volume49
Issue number7
DOIs
Publication statusPublished - Feb 11 2008

Fingerprint

Fucose
Sulfonic Acids
Neuraminidase
N-Acetylneuraminic Acid
Lactones
Glycosides
Assays
Derivatives

Keywords

  • Methyl glycosides
  • N-Acetylneuraminic acid analogues
  • Sulfonic acids
  • Thioglycosides

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

A first synthesis of sulfonic acid analogues of N-acetylneuraminic acid. / Szabó, Zoltán B.; Borbás, A.; Bajza, István; Lipták, A.; Antus, S.

In: Tetrahedron Letters, Vol. 49, No. 7, 11.02.2008, p. 1196-1198.

Research output: Contribution to journalArticle

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AU - Antus, S.

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