A family of laminin-related proteins controlling ectodermal differentiation in Drosophila

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Abstract

It is shown that the proteins encoded by the tumor suppressor fat gene, the neurogenic slit gene and crumbs gene of Drosophila contain domains homologous with modules identified previously in laminin A. These proteins of Drosophila have a number of features in common; they have large extracellular regions containing laminin A modules linked to epidermal growth factor-like domains, and they are all involved in cell-cell interactions that are crucial for correct morphogenesis or ectodermal tissues (development of midline neuroepithelia, organization of epihelial tissues etc.) It is suggested that the laminin A-type modules of these proteins play important roles in the interactions that control ectodermal differentiation.

Original languageEnglish
Pages (from-to)182-184
Number of pages3
JournalFEBS letters
Volume298
Issue number2-3
DOIs
Publication statusPublished - Feb 24 1992

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Keywords

  • Epithelial polarization
  • Laminin
  • Neurogenesis
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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