A facile synthesis of 3-(substituted benzyl)piperidines

B. Ágai, Adrienn Nádor, Ágnes Proszenyák, G. Tárkányi, F. Faigl

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A convenient new method has been developed for preparation a series of 3-(substituted benzyl)piperidines by addition of substituted phenylmagnesium bromide to pyridine-3-carboxaldehyde followed by one pot deoxygenation and heteroaromatic ring saturation in the presence of palladium catalyst.

Original languageEnglish
Pages (from-to)7897-7900
Number of pages4
JournalTetrahedron
Volume59
Issue number40
DOIs
Publication statusPublished - Sep 29 2003

Fingerprint

Piperidines
Palladium
Bromides
Catalysts
pyridine

Keywords

  • 3-Benzylpiperidine
  • Catalytic deoxygenation
  • Catalytic reduction
  • Grignard-reaction

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

A facile synthesis of 3-(substituted benzyl)piperidines. / Ágai, B.; Nádor, Adrienn; Proszenyák, Ágnes; Tárkányi, G.; Faigl, F.

In: Tetrahedron, Vol. 59, No. 40, 29.09.2003, p. 7897-7900.

Research output: Contribution to journalArticle

Ágai, B. ; Nádor, Adrienn ; Proszenyák, Ágnes ; Tárkányi, G. ; Faigl, F. / A facile synthesis of 3-(substituted benzyl)piperidines. In: Tetrahedron. 2003 ; Vol. 59, No. 40. pp. 7897-7900.
@article{dd9bb73d350f4d149912c55d93dca1e2,
title = "A facile synthesis of 3-(substituted benzyl)piperidines",
abstract = "A convenient new method has been developed for preparation a series of 3-(substituted benzyl)piperidines by addition of substituted phenylmagnesium bromide to pyridine-3-carboxaldehyde followed by one pot deoxygenation and heteroaromatic ring saturation in the presence of palladium catalyst.",
keywords = "3-Benzylpiperidine, Catalytic deoxygenation, Catalytic reduction, Grignard-reaction",
author = "B. {\'A}gai and Adrienn N{\'a}dor and {\'A}gnes Proszeny{\'a}k and G. T{\'a}rk{\'a}nyi and F. Faigl",
year = "2003",
month = "9",
day = "29",
doi = "10.1016/j.tet.2003.08.023",
language = "English",
volume = "59",
pages = "7897--7900",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Limited",
number = "40",

}

TY - JOUR

T1 - A facile synthesis of 3-(substituted benzyl)piperidines

AU - Ágai, B.

AU - Nádor, Adrienn

AU - Proszenyák, Ágnes

AU - Tárkányi, G.

AU - Faigl, F.

PY - 2003/9/29

Y1 - 2003/9/29

N2 - A convenient new method has been developed for preparation a series of 3-(substituted benzyl)piperidines by addition of substituted phenylmagnesium bromide to pyridine-3-carboxaldehyde followed by one pot deoxygenation and heteroaromatic ring saturation in the presence of palladium catalyst.

AB - A convenient new method has been developed for preparation a series of 3-(substituted benzyl)piperidines by addition of substituted phenylmagnesium bromide to pyridine-3-carboxaldehyde followed by one pot deoxygenation and heteroaromatic ring saturation in the presence of palladium catalyst.

KW - 3-Benzylpiperidine

KW - Catalytic deoxygenation

KW - Catalytic reduction

KW - Grignard-reaction

UR - http://www.scopus.com/inward/record.url?scp=0141628869&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141628869&partnerID=8YFLogxK

U2 - 10.1016/j.tet.2003.08.023

DO - 10.1016/j.tet.2003.08.023

M3 - Article

AN - SCOPUS:0141628869

VL - 59

SP - 7897

EP - 7900

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

IS - 40

ER -