A facile method for the preparation of 2,4-bis(diphenylphosphino)pentane (BDPP) enantiomers and their application in asymmetric hydrogenation

József Bakos, Imre Tóth, Bálint Heil, Lászlo Markó

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Abstract

Asymmetric heterogeneous hydrogenation of acetylacetone was applied for the preparation of both enantiomers (2R,4R and 2S,4S) of 2,4-bis(diphenylphosphino)pentane (BDPP). Among the chiral phosphines prepared up to now BDPP appears to be unique in the sense that its rhodium(I) complexes serve as effective homogeneous asymmetric hydrogenation catalysts not only for the reduction of Z-α-amidoacrylic acids but also for the reduction of α-ethylstyrene, acetophenone, and acetophenonebenzylimine. The analogous phosphinite ligand BDPOP yields a less selective catalyst.

Original languageEnglish
Pages (from-to)23-29
Number of pages7
JournalJournal of Organometallic Chemistry
Volume279
Issue number1-2
DOIs
Publication statusPublished - Jan 8 1985

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ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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