A dynorphinergic pathway of Leu-enkephalin production in rat substantia nigra

Nadav Zamir, Miklós Palkovits, Eckward Weber, Éva Mezey, Michael J. Brownstein

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The amino acid sequence of the opioid peptide Leu-enkephalin1-3 is found within several larger peptides4-8, which are generated from the precursors proenkephalin and prodynorphin. Proenkephalin contains four copies of the sequence of Met-enkephalin, a single copy of the sequence of Leu-enkephalin and one copy each of two extended Met-enkephalin sequences 9-11. Proenkephalin contains three peptides - α-neo-endorphin, dynorphin A and dynorphin B12 - the N-terminal sequences of which are identical to that of Leu-enkephalin. There is good evidence that the large amounts of Leu-enkephalin found in the adrenal medulla are generated from the precursor proenkephalin2,4,13,14, but as yet prodynorphin has not been shown to be processed to yield Leu-enkephalin. We show here that the relatively high levels of Leu-enkephalin found in the rat substantia nigra are supplied by striatonigral axons and generated from the precursor prodynorphin.

Original languageEnglish
Pages (from-to)643-645
Number of pages3
Issue number5952
Publication statusPublished - Dec 1 1984

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