A dynorphinergic pathway of Leu-enkephalin production in rat substantia nigra

Nadav Zamir, M. Palkóvits, Eckward Weber, Éva Mezey, Michael J. Brownstein

Research output: Contribution to journalArticle

163 Citations (Scopus)

Abstract

The amino acid sequence of the opioid peptide Leu-enkephalin1-3 is found within several larger peptides4-8, which are generated from the precursors proenkephalin and prodynorphin. Proenkephalin contains four copies of the sequence of Met-enkephalin, a single copy of the sequence of Leu-enkephalin and one copy each of two extended Met-enkephalin sequences 9-11. Proenkephalin contains three peptides - α-neo-endorphin, dynorphin A and dynorphin B12 - the N-terminal sequences of which are identical to that of Leu-enkephalin. There is good evidence that the large amounts of Leu-enkephalin found in the adrenal medulla are generated from the precursor proenkephalin2,4,13,14, but as yet prodynorphin has not been shown to be processed to yield Leu-enkephalin. We show here that the relatively high levels of Leu-enkephalin found in the rat substantia nigra are supplied by striatonigral axons and generated from the precursor prodynorphin.

Original languageEnglish
Pages (from-to)643-645
Number of pages3
JournalNature
Volume307
Issue number5952
DOIs
Publication statusPublished - 1984

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Leucine Enkephalin
Substantia Nigra
Dynorphins
Methionine Enkephalin
Endorphins
Adrenal Medulla
Opioid Peptides
Axons
Amino Acid Sequence
Peptides
preproenkephalin
proenkephalin

ASJC Scopus subject areas

  • General

Cite this

A dynorphinergic pathway of Leu-enkephalin production in rat substantia nigra. / Zamir, Nadav; Palkóvits, M.; Weber, Eckward; Mezey, Éva; Brownstein, Michael J.

In: Nature, Vol. 307, No. 5952, 1984, p. 643-645.

Research output: Contribution to journalArticle

Zamir, N, Palkóvits, M, Weber, E, Mezey, É & Brownstein, MJ 1984, 'A dynorphinergic pathway of Leu-enkephalin production in rat substantia nigra', Nature, vol. 307, no. 5952, pp. 643-645. https://doi.org/10.1038/307643a0
Zamir, Nadav ; Palkóvits, M. ; Weber, Eckward ; Mezey, Éva ; Brownstein, Michael J. / A dynorphinergic pathway of Leu-enkephalin production in rat substantia nigra. In: Nature. 1984 ; Vol. 307, No. 5952. pp. 643-645.
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AB - The amino acid sequence of the opioid peptide Leu-enkephalin1-3 is found within several larger peptides4-8, which are generated from the precursors proenkephalin and prodynorphin. Proenkephalin contains four copies of the sequence of Met-enkephalin, a single copy of the sequence of Leu-enkephalin and one copy each of two extended Met-enkephalin sequences 9-11. Proenkephalin contains three peptides - α-neo-endorphin, dynorphin A and dynorphin B12 - the N-terminal sequences of which are identical to that of Leu-enkephalin. There is good evidence that the large amounts of Leu-enkephalin found in the adrenal medulla are generated from the precursor proenkephalin2,4,13,14, but as yet prodynorphin has not been shown to be processed to yield Leu-enkephalin. We show here that the relatively high levels of Leu-enkephalin found in the rat substantia nigra are supplied by striatonigral axons and generated from the precursor prodynorphin.

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