A DSC and Raman spectroscopic study of microspheres preparedwith polar cosolvents by different techniques

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6 Citations (Scopus)

Abstract

A study was made of the possibilities of gradually decreasing the concentration of the toxic organic solvent in the process of microsphere preparation. Ammonio methacrylate copolymer-based microspheres were prepared by spray drying or conventional solvent evaporation techniques, and compared. The formulations were designed by varying the preparation methods and the concentrations of four polar cosolvents as independent variables. DSC was used to study the relationship between the changes in the independent variables and three of the main thermal events of the microspheres. Raman spectroscopy was used to investigate and confirm the possible interactions between drug and copolymer. Appropriate choice of the independent variables led to the molecularly dispersed drug in the polymer matrix. It was demonstrated that only the nature of the preparation method caused significant variations in the structure and thermal behaviour of the microspheres.

Original languageEnglish
Pages (from-to)109-118
Number of pages10
JournalJournal of Thermal Analysis and Calorimetry
Volume94
Issue number1
DOIs
Publication statusPublished - Oct 2008

Fingerprint

Microspheres
preparation
copolymers
drugs
Copolymers
Drug interactions
Spray drying
drying
sprayers
Methacrylates
Poisons
Raman spectroscopy
Polymer matrix
evaporation
Organic solvents
formulations
Evaporation
polymers
matrices
interactions

Keywords

  • Cosolvents
  • DSC
  • Energy-dispersive X-ray fluorescence analysis
  • Microsphere
  • Raman spectroscopy
  • Spray drying
  • W/O/W multiple emulsion

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Condensed Matter Physics

Cite this

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abstract = "A study was made of the possibilities of gradually decreasing the concentration of the toxic organic solvent in the process of microsphere preparation. Ammonio methacrylate copolymer-based microspheres were prepared by spray drying or conventional solvent evaporation techniques, and compared. The formulations were designed by varying the preparation methods and the concentrations of four polar cosolvents as independent variables. DSC was used to study the relationship between the changes in the independent variables and three of the main thermal events of the microspheres. Raman spectroscopy was used to investigate and confirm the possible interactions between drug and copolymer. Appropriate choice of the independent variables led to the molecularly dispersed drug in the polymer matrix. It was demonstrated that only the nature of the preparation method caused significant variations in the structure and thermal behaviour of the microspheres.",
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AU - Sípos, P.

AU - Szabó, A.

AU - Erös, I.

AU - Szabó-Révész, P.

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N2 - A study was made of the possibilities of gradually decreasing the concentration of the toxic organic solvent in the process of microsphere preparation. Ammonio methacrylate copolymer-based microspheres were prepared by spray drying or conventional solvent evaporation techniques, and compared. The formulations were designed by varying the preparation methods and the concentrations of four polar cosolvents as independent variables. DSC was used to study the relationship between the changes in the independent variables and three of the main thermal events of the microspheres. Raman spectroscopy was used to investigate and confirm the possible interactions between drug and copolymer. Appropriate choice of the independent variables led to the molecularly dispersed drug in the polymer matrix. It was demonstrated that only the nature of the preparation method caused significant variations in the structure and thermal behaviour of the microspheres.

AB - A study was made of the possibilities of gradually decreasing the concentration of the toxic organic solvent in the process of microsphere preparation. Ammonio methacrylate copolymer-based microspheres were prepared by spray drying or conventional solvent evaporation techniques, and compared. The formulations were designed by varying the preparation methods and the concentrations of four polar cosolvents as independent variables. DSC was used to study the relationship between the changes in the independent variables and three of the main thermal events of the microspheres. Raman spectroscopy was used to investigate and confirm the possible interactions between drug and copolymer. Appropriate choice of the independent variables led to the molecularly dispersed drug in the polymer matrix. It was demonstrated that only the nature of the preparation method caused significant variations in the structure and thermal behaviour of the microspheres.

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KW - Energy-dispersive X-ray fluorescence analysis

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KW - Spray drying

KW - W/O/W multiple emulsion

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