Széklethemoglobin és -albumin kettos immunkémiai vizsgálat colorectalis szurésnél.

Translated title of the contribution: [A double immunochemical method for detecting faecal haemoglobin and albumin in rectal screening].

Adám Tarpay, Mária Szabadosné Németh, Enikõ Orosz, Miklós Kásler, Mária Burai, Akos Pap, Szabolcs Ottó

Research output: Contribution to journalArticle

Abstract

Undoubtedly, colonoscopy is the "gold standard" in the diagnosis of colorectal cancers. Sophisticated bowel preparation and risk of bowel perforation and bleeding, as well as the patient's discomfort during examination lead to low compliance in screening. Therefore, alternative non-invasive screening methods tend to come into the fore. In this study we compared the sensitivity and specificity of the double immunochemical FECA test for the haemoglobin + albumin content of the faeces with those of control colonoscopy in the detection of colorectal neoplasms. In a 3-year period 154 patients (69 males and 85 females) were scheduled for colonoscopy with previously collected stool samples. The sensitivity and specificity of the double immunochemical test for faecal haemoglobin + albumin content were determined in colorectal neoplasms of different severity. Colonoscopy served as a control examination. Colonoscopy identified in 77 cases benign lesions, and in 10 cases malignant tumours. The double immunochemical test for faecal blood and protein successfully used in model screening population showed in our present study 52.7% sensitivity and 92.3% specificity for significant neoplastic lesions (high-risk polyps and tumours). When the evaluation was limited to the high-risk polyps, the sensitivity was modified to 45.5% and the specificity to 92.3% and in case of invasive tumours to 90% and 100%, respectively. If only faecal haemoglobin content was measured, the overall sensitivity for polyps of any size and sort was 15.7% which, however, increased to 27.63% if faecal albumin was also measured. Based on relevant literature, the sensitivity of the FECA test for colorectal polyp and cancer is more favourable than that of other FITs. However, the increased sensitivity of the double faecal protein test falls short of the standard colonoscopy. Therefore, in certain cases the latter might be considered as a primary screening method.

Original languageHungarian
Pages (from-to)268-273
Number of pages6
JournalMagyar Onkologia
Volume55
Issue number4
Publication statusPublished - Nov 2011
Externally publishedYes

Fingerprint

Colonoscopy
Albumins
Hemoglobins
Polyps
Colorectal Neoplasms
Sensitivity and Specificity
Neoplasms
Feces
Compliance
Blood Proteins
Hemorrhage
Population
Proteins

ASJC Scopus subject areas

  • Oncology

Cite this

Tarpay, A., Szabadosné Németh, M., Orosz, E., Kásler, M., Burai, M., Pap, A., & Ottó, S. (2011). Széklethemoglobin és -albumin kettos immunkémiai vizsgálat colorectalis szurésnél. Magyar Onkologia, 55(4), 268-273.

Széklethemoglobin és -albumin kettos immunkémiai vizsgálat colorectalis szurésnél. / Tarpay, Adám; Szabadosné Németh, Mária; Orosz, Enikõ; Kásler, Miklós; Burai, Mária; Pap, Akos; Ottó, Szabolcs.

In: Magyar Onkologia, Vol. 55, No. 4, 11.2011, p. 268-273.

Research output: Contribution to journalArticle

Tarpay, A, Szabadosné Németh, M, Orosz, E, Kásler, M, Burai, M, Pap, A & Ottó, S 2011, 'Széklethemoglobin és -albumin kettos immunkémiai vizsgálat colorectalis szurésnél.', Magyar Onkologia, vol. 55, no. 4, pp. 268-273.
Tarpay A, Szabadosné Németh M, Orosz E, Kásler M, Burai M, Pap A et al. Széklethemoglobin és -albumin kettos immunkémiai vizsgálat colorectalis szurésnél. Magyar Onkologia. 2011 Nov;55(4):268-273.
Tarpay, Adám ; Szabadosné Németh, Mária ; Orosz, Enikõ ; Kásler, Miklós ; Burai, Mária ; Pap, Akos ; Ottó, Szabolcs. / Széklethemoglobin és -albumin kettos immunkémiai vizsgálat colorectalis szurésnél. In: Magyar Onkologia. 2011 ; Vol. 55, No. 4. pp. 268-273.
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