A cost-effective synthesis of enantiopure ovothiol A from L-histidine, its natural precursor

Arash Mirzahosseini, Sándor Hosztafi, Gergo Tóth, B. Noszál

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Ovothiol A is a naturally occurring 4-mercaptohistidine derivative, and one of the most potent thiol-containing antioxidants. The synthesis of ovothiol A was elaborated by introducing the thiol group onto protected 3-methyl-L-histidine via halogenation and Ullmann reaction. This enantiopure synthesis of ovothiol A, which uses L-histidine as starting material, requires only five steps, and compared to prior synthesis, is both cost and time effiecent.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalArkivoc
Volume2014
Issue number6
DOIs
Publication statusPublished - Sep 26 2014

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Histidine
Sulfhydryl Compounds
Halogenation
Costs
Antioxidants
Derivatives
ovothiol A

Keywords

  • Antioxidant
  • Histidine
  • Ovothiol
  • Trypanosomatid

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

A cost-effective synthesis of enantiopure ovothiol A from L-histidine, its natural precursor. / Mirzahosseini, Arash; Hosztafi, Sándor; Tóth, Gergo; Noszál, B.

In: Arkivoc, Vol. 2014, No. 6, 26.09.2014, p. 1-9.

Research output: Contribution to journalArticle

Mirzahosseini, Arash ; Hosztafi, Sándor ; Tóth, Gergo ; Noszál, B. / A cost-effective synthesis of enantiopure ovothiol A from L-histidine, its natural precursor. In: Arkivoc. 2014 ; Vol. 2014, No. 6. pp. 1-9.
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