A corpus luteum is nota prerequisite for the expression of progesterone induced blocking factor by T-lymphocytes a week after implantation

Jerome H. Check, J. Szekeres-Barthó, Parvin Nazari, Youval Katz, Matthew L. Check

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: To determine if production of the immunomodulatory protein, progesterone induced blocking factor (pibf), requires merely progesterone or whether other factors made by the corpus luteum are required. Methods: The percentage of peripheral lymphocytes expressing PIBF was determined by obtaining a blood sample from women 9-12 days after embryo transfer. The embryos were either fresh ones following hyperstimulation and oocyte retrieval or were frozen-thawed embryos. Preparation for frozen embryo transfer required corpus luteum suppression with exogenous estrogen. The percentage of lymphocytes expressing PIBF was determined by an immunocytochemistry method. Results: PIBF expression (>1%) was found in 20.5% of COH and 13.3% of frozen embryo transfer cycles. There either was a significant difference or a trend for higher pregnancy rates when PIBF expression was detected. Conclusions: These data corroborate previous conclusions that PIBF is detected in a minority of women in the late luteal phase. A corpus luteum is not required for its expression.

Original languageEnglish
Pages (from-to)603-607
Number of pages5
JournalJournal of Assisted Reproduction and Genetics
Volume18
Issue number11
DOIs
Publication statusPublished - 2001

Fingerprint

Embryo Transfer
Corpus Luteum
Progesterone
T-Lymphocytes
Embryonic Structures
Lymphocytes
Oocyte Retrieval
Luteal Phase
Pregnancy Rate
Estrogens
Immunohistochemistry
blocking factor
Proteins

Keywords

  • Corpus luteum
  • Immunomodulatory protein
  • Progesterone

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Developmental Biology
  • Genetics
  • Reproductive Medicine

Cite this

A corpus luteum is nota prerequisite for the expression of progesterone induced blocking factor by T-lymphocytes a week after implantation. / Check, Jerome H.; Szekeres-Barthó, J.; Nazari, Parvin; Katz, Youval; Check, Matthew L.

In: Journal of Assisted Reproduction and Genetics, Vol. 18, No. 11, 2001, p. 603-607.

Research output: Contribution to journalArticle

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AU - Check, Matthew L.

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