A Coordination Chemistry Approach to Fine-Tune the Physicochemical Parameters of Lanthanide Complexes Relevant to Medical Applications

Mariane Le Fur, Enikő Molnár, Maryline Beyler, Ferenc K. Kálmán, Olivier Fougère, David Esteban-Gómez, Olivier Rousseaux, Raphaël Tripier, G. Tircsó, Carlos Platas-Iglesias

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The geometric features of two pyclen-based ligands possessing identical donor atoms but different site organization have a profound impact in their complexation properties toward lanthanide ions. The ligand containing two acetate groups and a picolinate arm arranged in a symmetrical fashion (L1) forms a Gd3+ complex being two orders of magnitude less stable than its dissymmetric analogue GdL2. Besides, GdL1 experiences a much faster dissociation following the acid-catalyzed mechanism than GdL2. On the contrary, GdL1 exhibits a lower exchange rate of the coordinated water molecule compared to GdL2. These very different properties are related to different strengths of the Gd-ligand bonds associated to steric effects, which hinder the coordination of a water molecule in GdL2 and the binding of acetate groups in GdL1.

Original languageEnglish
Pages (from-to)3127-3131
Number of pages5
JournalChemistry - A European Journal
Volume24
Issue number13
DOIs
Publication statusPublished - Mar 2 2018

    Fingerprint

Keywords

  • lanthanides
  • macrocycles
  • MRI
  • NMR spectroscopy
  • water exchange

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Le Fur, M., Molnár, E., Beyler, M., Kálmán, F. K., Fougère, O., Esteban-Gómez, D., Rousseaux, O., Tripier, R., Tircsó, G., & Platas-Iglesias, C. (2018). A Coordination Chemistry Approach to Fine-Tune the Physicochemical Parameters of Lanthanide Complexes Relevant to Medical Applications. Chemistry - A European Journal, 24(13), 3127-3131. https://doi.org/10.1002/chem.201705528