A Convenient Synthesis of Pyrrolo[3,4-c]quinolines

A. Virányi, Miklós Nyerges, Gábor Blaskó, L. Tőke

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A new route to the pyrrolo[3,4-c]quinoline ring system has been developed. The synthesis proceeds stereoselectively in three steps, using 1,3-dipolar cycloaddition of azomethine ylides as a key step. First, a series of 4-arylpyrrolidine-3-carboxyiic acids have been prepared from the appropriate cinnamic esters and a non-stabilized azomethine ylide. The reduction of a nitro group on the aromatic ring was followed by acid-catalyzed intramolecular lactam formation.

Original languageEnglish
Pages (from-to)2655-2660
Number of pages6
JournalSynthesis
Issue number17
Publication statusPublished - 2003

Fingerprint

Quinolines
Lactams
Acids
Cycloaddition
Esters
azomethine
quinoline

Keywords

  • Amino acids
  • Cyclizations
  • Cycloaddition
  • Lactams
  • Quinolines

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Virányi, A., Nyerges, M., Blaskó, G., & Tőke, L. (2003). A Convenient Synthesis of Pyrrolo[3,4-c]quinolines. Synthesis, (17), 2655-2660.

A Convenient Synthesis of Pyrrolo[3,4-c]quinolines. / Virányi, A.; Nyerges, Miklós; Blaskó, Gábor; Tőke, L.

In: Synthesis, No. 17, 2003, p. 2655-2660.

Research output: Contribution to journalArticle

Virányi, A, Nyerges, M, Blaskó, G & Tőke, L 2003, 'A Convenient Synthesis of Pyrrolo[3,4-c]quinolines', Synthesis, no. 17, pp. 2655-2660.
Virányi, A. ; Nyerges, Miklós ; Blaskó, Gábor ; Tőke, L. / A Convenient Synthesis of Pyrrolo[3,4-c]quinolines. In: Synthesis. 2003 ; No. 17. pp. 2655-2660.
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