A convenient synthesis of diastereomeric synthons: Ethyl 3-methyl-1,2,3,4-tetrahydroisoquinoline-1-acetates by direct and reverse substituent introductions

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Abstract

The two diastereomers of ethyl 3-methyl-1,2,3,4-tetrahydroisoquinoline-1-acetate (4 and 5) were synthesized from l-(3′,4′-dimethoxyphenyl)isopropylamine (1) by direct and reverse substituent introductions. The cause of the diastereo-stereoselectivity is rationalized.

Original languageEnglish
Pages (from-to)1605-1606
Number of pages2
JournalHeterocycles
Volume43
Issue number8
Publication statusPublished - Dec 1 1996

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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