A convenient regioselective synthesis of pyrano[3,2-b]acridones involving nucleophilic addition to benzyne

Mónika Rudas, Miklós Nyerges, L. Tőke, Béla Pete, Paul W. Groundwater

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Acridone 8 was prepared by the nucleophilic addition of aniline 4 to benzyne 5. Hydrolysis of the ester group, followed by cyclisation gave the acridone 8, which was subsequently converted to the pyrano[3,2-b]acridin-4-ones 11 and 17.

Original languageEnglish
Pages (from-to)7003-7006
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number38
DOIs
Publication statusPublished - Sep 17 1999

Fingerprint

Acridones
Cyclization
Hydrolysis
Esters
acridone
benzyne

Keywords

  • Acridines
  • Alkaloids
  • Arynes
  • Pyrones

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

A convenient regioselective synthesis of pyrano[3,2-b]acridones involving nucleophilic addition to benzyne. / Rudas, Mónika; Nyerges, Miklós; Tőke, L.; Pete, Béla; Groundwater, Paul W.

In: Tetrahedron Letters, Vol. 40, No. 38, 17.09.1999, p. 7003-7006.

Research output: Contribution to journalArticle

Rudas, Mónika ; Nyerges, Miklós ; Tőke, L. ; Pete, Béla ; Groundwater, Paul W. / A convenient regioselective synthesis of pyrano[3,2-b]acridones involving nucleophilic addition to benzyne. In: Tetrahedron Letters. 1999 ; Vol. 40, No. 38. pp. 7003-7006.
@article{b399274607824820af432235160c93b5,
title = "A convenient regioselective synthesis of pyrano[3,2-b]acridones involving nucleophilic addition to benzyne",
abstract = "Acridone 8 was prepared by the nucleophilic addition of aniline 4 to benzyne 5. Hydrolysis of the ester group, followed by cyclisation gave the acridone 8, which was subsequently converted to the pyrano[3,2-b]acridin-4-ones 11 and 17.",
keywords = "Acridines, Alkaloids, Arynes, Pyrones",
author = "M{\'o}nika Rudas and Mikl{\'o}s Nyerges and L. Tőke and B{\'e}la Pete and Groundwater, {Paul W.}",
year = "1999",
month = "9",
day = "17",
doi = "10.1016/S0040-4039(99)01424-0",
language = "English",
volume = "40",
pages = "7003--7006",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "38",

}

TY - JOUR

T1 - A convenient regioselective synthesis of pyrano[3,2-b]acridones involving nucleophilic addition to benzyne

AU - Rudas, Mónika

AU - Nyerges, Miklós

AU - Tőke, L.

AU - Pete, Béla

AU - Groundwater, Paul W.

PY - 1999/9/17

Y1 - 1999/9/17

N2 - Acridone 8 was prepared by the nucleophilic addition of aniline 4 to benzyne 5. Hydrolysis of the ester group, followed by cyclisation gave the acridone 8, which was subsequently converted to the pyrano[3,2-b]acridin-4-ones 11 and 17.

AB - Acridone 8 was prepared by the nucleophilic addition of aniline 4 to benzyne 5. Hydrolysis of the ester group, followed by cyclisation gave the acridone 8, which was subsequently converted to the pyrano[3,2-b]acridin-4-ones 11 and 17.

KW - Acridines

KW - Alkaloids

KW - Arynes

KW - Pyrones

UR - http://www.scopus.com/inward/record.url?scp=0033578886&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033578886&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(99)01424-0

DO - 10.1016/S0040-4039(99)01424-0

M3 - Article

VL - 40

SP - 7003

EP - 7006

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 38

ER -