A convenient approach for the preparation of imidazo[1,2-: A] -fused bicyclic frameworks via IBX/NIS promoted oxidative annulation

Zsófia Makra, László G. Puskás, Iván Kanizsai

Research output: Contribution to journalArticle

Abstract

An IBX/NIS-induced intramolecular oxidative annulation of Mannich-type substrates is reported. This metal-free approach involving iodination, NH-oxidation, intramolecular C-N bond formation, and retro-Claisen-Schmidt sequence provides the construction of imidazo[1,2-a]pyridine, imidazo[1,2-a]pyrimidine as well as imidazo[1,2-a]pyrazine frameworks with yields up to 93%. In addition, a sequential one-pot process is also presented.

Original languageEnglish
Pages (from-to)9001-9007
Number of pages7
JournalOrganic and Biomolecular Chemistry
Volume17
Issue number40
DOIs
Publication statusPublished - Jan 1 2019

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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