A convenient and highly stereoselective synthesis of 14-substituted 8,13-diazaoestrone analogues by domino ring closures

László Lázár, Henri Kivelä, Kalevi Pihlaja, Ferenc Fülöp

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

By means of convenient domino ring closure reactions of 1-(2-aminoethyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 2 and γ-oxo-acids, 14-substituted 8,13-diazaoestrone derivatives (5 and 6) were formed with ∼100% diastereoselectivity.

Original languageEnglish
Pages (from-to)6199-6201
Number of pages3
JournalTetrahedron Letters
Volume45
Issue number32
DOIs
Publication statusPublished - Aug 2 2004

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Keywords

  • Azasteroids
  • Diamines
  • Domino reactions
  • Isoquinolines
  • Stereoselective synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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