A conserved linkage group on chromosome 6, the 8.1 ancestral haplotype, is a predisposing factor of chronic rhinosinusitis associated with nasal polyposis in aspirin-sensitive Hungarians

Kornélia Szabó, Hilda Polyánka, Ágnes Kiricsi, Mónika Révész, Ida Vóna, Zsolt Szabó, Zsolt Bella, Edit Kadocsa, Lajos Kemény, Márta Széll, Andor Hirschberg

Research output: Contribution to journalArticle

Abstract

Inflammation plays a central role in the pathogenesis of chronic rhinosinusitis (CRS), and TNFα is a key pro-inflammatory cytokine in the pathogenesis of this disease. In our previous studies, we showed that the TNFA -308A allele is a genetic predisposition factor in a subgroup of aspirin-sensitive (ASA+) CRS patients suffering from nasal polyps (NP) in the Hungarian population.To determine whether the TNF -308A allele or the presence of a complex, extended ancestral haplotype (8.1AH) located on chromosome 6 is responsible for the previously observed genetic effect, we performed a case-control study for examining the frequency of 8.1AH carriers in controls and in subgroups of CRS patients.Our novel observations demonstrate that the presence of the 8.1AH may be responsible for the development of severe forms of CRS (CRSwNP, ASA+) and strengthen the clinical observation that CRS patients can be classified into clinically and genetically different subgroups.

Original languageEnglish
Pages (from-to)858-862
Number of pages5
JournalHuman Immunology
Volume76
Issue number11
DOIs
Publication statusPublished - Nov 2015

Keywords

  • 8.1 ancestral haplotype (8.1AH)
  • Chronic rhinosinusitis (CRS)
  • Nasal polyp (NP)
  • Single nucleotide polymorphism (SNP)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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