A comprehensive appraisal on Crocus chrysanthus (Herb.) Herb. flower extracts with HPLC–MS/MS profiles, antioxidant and enzyme inhibitory properties

Gokhan Zengin, Muhammad Zakariyyah Aumeeruddy, Alina Diuzheva, J. Jekó́, Zoltán Cziáky, Aysegul Yıldıztugay, Evren Yıldıztugay, Mohamad Fawzi Mahomoodally

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In the quest for new drugs of herbal origin, the ethyl acetate (EAE), methanol (ME), and water (WE) extracts of Crocus chrysanthus (Herb.) Herb. flowers were analyzed for their polyphenolic composition, antioxidant, and enzyme inhibitory potential. WE showed the highest antioxidant activities in all assays including metal chelating, phosphomolybdenum, FRAP, CUPRAC, ABTS and DPPH. EAE was the most effective enzyme inhibitor, exhibiting the highest inhibition against some enzymes linked to Alzheimer's disease (cholinesterases), diabetes mellitus (α-glucosidase and α-amylase) and hyperpigmentation problems (tyrosinase). The highest total phenolics (34.99 mg GAE/g) and flavonoids content (77.58 mg RE/g) were observed in WE and ME, respectively. Eight compounds were identified in EAE, 24 in ME, and 15 in WE. Kaempferol 3-O glucoside was found in all extracts. In conclusion, C. chrysanthus flowers can be suggested as a source of bioactive components with potential use against chronic disorders caused by oxidative stress. Future in-depth studies are recommended to determine the biological effects of isolated compounds from C. chrysanthus to identify the main compounds modulating the observed activities.

Original languageEnglish
Pages (from-to)581-589
Number of pages9
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume164
DOIs
Publication statusPublished - Feb 5 2019

Keywords

  • Crocus chrysanthus
  • Enzyme inhibitor
  • Oxidative stress
  • Polyphenolic

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science
  • Drug Discovery
  • Spectroscopy
  • Clinical Biochemistry

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