A combined method for the determination of myocardial perfusion in experimental animals using microspheres and CMR

Pál Surányi, Pál Kiss, T. Símor, Ada Elgavish, Gabriel A. Elgavish

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A convenient method is introduced for myocardial perfusion research by combining multislice short-axis cine cardiovascular magnetic resonance (MSA-CMR) and colored microspheres (CM). In canine control-ischemia-reperfusion (n = 11), Cardiac output (CO) was measured using MSA-CMR (COMSA), Phase Contrast CMR (PC-CMR, COPC) and CM (from reference blood samples, COμ) in 3 experimental periods per animal. COμ significantly and systematically overestimated COMSA (median deviation: 291 mL/min, p <0.01), while there was excellent agreement between PC-CMR and MSA-CMR without significant over-or underestimation (median deviation: -14 ml/min, p = NS). In quantitative myocardial perfusion assay by CM, CMR should be used instead of reference blood sampling. This should improve the accuracy of absolute regional perfusion measurement.

Original languageEnglish
Pages (from-to)549-556
Number of pages8
JournalJournal of Cardiovascular Magnetic Resonance
Volume9
Issue number3
DOIs
Publication statusPublished - May 2007

Fingerprint

Microspheres
Cardiac Output
Magnetic Resonance Spectroscopy
Perfusion
Reperfusion
Canidae
Ischemia
Research

Keywords

  • Cine CMR
  • Microspheres
  • Myocardial Ischemia
  • Myocardial Perfusion
  • Phase Contrast CMR

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Family Practice

Cite this

A combined method for the determination of myocardial perfusion in experimental animals using microspheres and CMR. / Surányi, Pál; Kiss, Pál; Símor, T.; Elgavish, Ada; Elgavish, Gabriel A.

In: Journal of Cardiovascular Magnetic Resonance, Vol. 9, No. 3, 05.2007, p. 549-556.

Research output: Contribution to journalArticle

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