A combined method for the determination of myocardial perfusion in experimental animals using microspheres and CMR

Pál Surányi, Pál Kiss, Tamás Simor, Ada Elgavish, Gabriel A. Elgavish

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A convenient method is introduced for myocardial perfusion research by combining multislice short-axis cine cardiovascular magnetic resonance (MSA-CMR) and colored microspheres (CM). In canine control-ischemia-reperfusion (n = 11), Cardiac output (CO) was measured using MSA-CMR (COMSA), Phase Contrast CMR (PC-CMR, COPC) and CM (from reference blood samples, COμ) in 3 experimental periods per animal. COμ significantly and systematically overestimated COMSA (median deviation: 291 mL/min, p < 0.01), while there was excellent agreement between PC-CMR and MSA-CMR without significant over-or underestimation (median deviation: -14 ml/min, p = NS). In quantitative myocardial perfusion assay by CM, CMR should be used instead of reference blood sampling. This should improve the accuracy of absolute regional perfusion measurement.

Original languageEnglish
Pages (from-to)549-556
Number of pages8
JournalJournal of Cardiovascular Magnetic Resonance
Volume9
Issue number3
DOIs
Publication statusPublished - May 1 2007

Keywords

  • Cine CMR
  • Microspheres
  • Myocardial Ischemia
  • Myocardial Perfusion
  • Phase Contrast CMR

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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