A combined electrophysiological and behavioural study for the assessment of activity-dependent changes in mice

Katalin Kóródi, Andrea Bite, Emöke Borbély, G. Kovács, Anett Nagy, Z. Süle, J. Toldi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Activity-dependent adaptive changes in the nervous system involve structural and functional changes in the cortical circuitry. In this work the cortical function was studied by repeated recording of the somatosensory and motor potentials evoked by whisker deflections after altered sensory-motor experience in adult mice. The latencies of motor and somatosensory evoked potentials were found to shorten, while their amplitudes decreased, after a behavioural challenge involving the vibrissal apparatus. Sensory deprivation achieved by whisker trimming resulted in a partial reversal of the changes observed after increased activity. The derived parameters imply that cortical information processing speeds up as a result of experience, while decreased activity has the opposite effect. The methods used throughout the experiment were minimally invasive, and thus proved to be sufficient for the long-term follow-up of cortical functions.

Original languageEnglish
Pages (from-to)85-94
Number of pages10
JournalActa Biologica Hungarica
Volume53
Issue number1-2
DOIs
Publication statusPublished - 2002

Fingerprint

functional change
Vibrissae
Motor Evoked Potentials
evoked potentials
Somatosensory Evoked Potentials
information processing
nervous system
deflection
structural change
Bioelectric potentials
Sensory Deprivation
mice
Automatic Data Processing
Nervous System
Trimming
experiment
Neurology
speed
parameter
method

Keywords

  • Barrel cortex
  • Evoked potential
  • Experience-dependent plasticity
  • Mice

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

A combined electrophysiological and behavioural study for the assessment of activity-dependent changes in mice. / Kóródi, Katalin; Bite, Andrea; Borbély, Emöke; Kovács, G.; Nagy, Anett; Süle, Z.; Toldi, J.

In: Acta Biologica Hungarica, Vol. 53, No. 1-2, 2002, p. 85-94.

Research output: Contribution to journalArticle

Kóródi, Katalin ; Bite, Andrea ; Borbély, Emöke ; Kovács, G. ; Nagy, Anett ; Süle, Z. ; Toldi, J. / A combined electrophysiological and behavioural study for the assessment of activity-dependent changes in mice. In: Acta Biologica Hungarica. 2002 ; Vol. 53, No. 1-2. pp. 85-94.
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