The aim of this study was to determine the effect of a lactoperoxidase-hypothiocyanate enzyme system on the microbiological flora and cytological picture in oral leukoplakia, and in oral lichen patients with associated dryness of the oral mucosa. Forty-one patients were divided into two groups; each used Biotene toothpaste. The test group additionally used Oralbalance gel three times a day, for a four-week period. At the end of four weeks the group using Biotene toothpaste alone reported improvement in the severity of the subjective complaints, and the group using Oralbalance gel showed a significant improvement (p < 0.05) compared to baseline measures. The presence of lactobacilli and Streptococcus mutans in saliva were slightly decreased in the test group, but this effect was not statistically significant. Exfoliative cytological examinations showed improvement in both groups. The decrease in the number of inflammatory cells was statistically significant in the gingival smears (p < 0.001), as well as in the buccal smears (p < 0.01). The keratinization index of the gingiva showed a statistically significant (p < 0.01) increase in the test group. These results point to early signs of improvement with oral dryness, many observable before clinical improvement occurs.
|Number of pages||5|
|Journal||Journal of Clinical Dentistry|
|Publication status||Published - Dec 16 1994|
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