A clinical feasibility study to evaluate the safety and efficacy of PEOT/PBT implants for human donor site filling during mosaicplasty

L. Hangody, Lajos Bartha, Doreen Hamann, Jeroen Pieper, Fabiènne Péters, Jens Riesle, Andras Vajda, Pal Kaposi Novak, Laszlo Rudolf Hangody, Gabor Vasarhelyi, Laszlo Bodó, Clemens Van Blitterswijk, Joost De Wijn, Annamaria Kenyeres, Laszlo Modis, Eszter Balo

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Mosaicplasty has become a well-accepted treatment modality for articular cartilage lesions in the knee. Postoperative bleeding remains potentially concerning. This study evaluates the porous poly(ethylene oxide)terephthalate/ poly(butylene terephthalate) (PEOT/PBT) implants used for donor site filling. Empty donor sites were the controls. After 9 months, MRI, macroscopical and histological analysis were carried out. Treated defects did not cause postoperative bleeding. No adverse events or inflammatory response was observed. PEOT/PBT implants were well integrated. Empty controls occasionally showed protrusion of repair tissue at the defect margins. Surface stiffness was minimally improved compared to controls. Existing polymer fragments indicated considerable biodegradation. Histological evaluation of the filled donor sites revealed congruent fibrocartilaginous surface repair with proteoglycan-rich domains and subchondral cancellous bone formation with interspersed fibrous tissue in all implanted sites. The PEOT/PBT implants successfully reduce donor site morbidity and postoperative bleeding after mosaicplasty. Level of evidence: II.

Original languageEnglish
Pages (from-to)81-91
Number of pages11
JournalEuropean Journal of Orthopaedic Surgery and Traumatology
Volume23
Issue number1
DOIs
Publication statusPublished - Jan 2013

Fingerprint

Ethylene Oxide
Feasibility Studies
Safety
Hemorrhage
Articular Cartilage
Proteoglycans
Osteogenesis
terephthalic acid
butylene
Clinical Studies
Knee
Polymers
Morbidity

Keywords

  • Biocompatibility
  • Biodegradation
  • Bone remodeling
  • Cartilage
  • Copolymer
  • In vivo

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

A clinical feasibility study to evaluate the safety and efficacy of PEOT/PBT implants for human donor site filling during mosaicplasty. / Hangody, L.; Bartha, Lajos; Hamann, Doreen; Pieper, Jeroen; Péters, Fabiènne; Riesle, Jens; Vajda, Andras; Novak, Pal Kaposi; Hangody, Laszlo Rudolf; Vasarhelyi, Gabor; Bodó, Laszlo; Van Blitterswijk, Clemens; De Wijn, Joost; Kenyeres, Annamaria; Modis, Laszlo; Balo, Eszter.

In: European Journal of Orthopaedic Surgery and Traumatology, Vol. 23, No. 1, 01.2013, p. 81-91.

Research output: Contribution to journalArticle

Hangody, L, Bartha, L, Hamann, D, Pieper, J, Péters, F, Riesle, J, Vajda, A, Novak, PK, Hangody, LR, Vasarhelyi, G, Bodó, L, Van Blitterswijk, C, De Wijn, J, Kenyeres, A, Modis, L & Balo, E 2013, 'A clinical feasibility study to evaluate the safety and efficacy of PEOT/PBT implants for human donor site filling during mosaicplasty', European Journal of Orthopaedic Surgery and Traumatology, vol. 23, no. 1, pp. 81-91. https://doi.org/10.1007/s00590-011-0907-6
Hangody, L. ; Bartha, Lajos ; Hamann, Doreen ; Pieper, Jeroen ; Péters, Fabiènne ; Riesle, Jens ; Vajda, Andras ; Novak, Pal Kaposi ; Hangody, Laszlo Rudolf ; Vasarhelyi, Gabor ; Bodó, Laszlo ; Van Blitterswijk, Clemens ; De Wijn, Joost ; Kenyeres, Annamaria ; Modis, Laszlo ; Balo, Eszter. / A clinical feasibility study to evaluate the safety and efficacy of PEOT/PBT implants for human donor site filling during mosaicplasty. In: European Journal of Orthopaedic Surgery and Traumatology. 2013 ; Vol. 23, No. 1. pp. 81-91.
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