A case of interstitial pneumonitis in a patients with ulcerative colitis treated with azathioprine

F. Nagy, T. Molnár, Eva Makula, Ildiko Kiss, Peter Milassin, Eva Zollei, L. Tiszlavicz, J. Lonovics

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The early hypersensitivity reaction and late bone marrow depression are well-known side-effects of azathioprine, whereas interstitial pneumonia is a rare complication. A 40-year old male patient had been treated with azathioprine in consequence of extensive ulcerative colitis for 10 years. He then complained of 7 d of fever, cough and catarrhal signs, without symptoms of active colitis. Opportunistic infections were ruled out. The chest X-ray, CT and lung biopsy demonstrated the presence of interstitial inflammation. Azathioprine therapy was discontinued as a potential source of the pulmonary infiltrate. In response to steroid therapy, and intensive care, the pulmonary infiltrate gradually decreased within 4 wk. Three months later, his ulcerative colitis relapsed, and ileo-anal pouch surgery was performed. In cases of atypical pneumonia, without a proven infection, azathioprine-associated interstitial pneumonitis may be present, which heals after withdrawal of the drug.

Original languageEnglish
Pages (from-to)316-319
Number of pages4
JournalWorld Journal of Gastroenterology
Volume13
Issue number2
Publication statusPublished - Jan 14 2007

Fingerprint

Interstitial Lung Diseases
Azathioprine
Ulcerative Colitis
Lung
X Ray Computed Tomography
Opportunistic Infections
Colitis
Critical Care
Cough
Signs and Symptoms
Pneumonia
Hypersensitivity
Fever
Thorax
Bone Marrow
Steroids
Inflammation
Biopsy
Therapeutics
Infection

Keywords

  • Azathioprine
  • Inflammatory bowel disease
  • Interstitial pneumonitis
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

A case of interstitial pneumonitis in a patients with ulcerative colitis treated with azathioprine. / Nagy, F.; Molnár, T.; Makula, Eva; Kiss, Ildiko; Milassin, Peter; Zollei, Eva; Tiszlavicz, L.; Lonovics, J.

In: World Journal of Gastroenterology, Vol. 13, No. 2, 14.01.2007, p. 316-319.

Research output: Contribution to journalArticle

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