Glükózszenzitív insulinoma mérsékelten emelkedett széruminzulinszinttel, eltávolítása után is fennmaradó epilepsziás rohamokkal

Translated title of the contribution: A case of glucose-sensitive insulinoma accompanied by slightly elevated serum insulin levels and persisting convulsions after the surgically removed neuroendocrine tumor

Zsuzsanna Soós, Anna Czégeni, Ferenc Salamon, Mónika Salamon, I. Kenessey, András Folyovich, Tibor Tihanyi, G. Winkler

Research output: Contribution to journalArticle

Abstract

Insul(in)oma is a usually solitary or, in some cases, multifocal tumor of pancreatic beta cells. It may be a component of multiple endocrine neoplasia type 1. or von Hippel-Lindau syndrome. In typical forms the diagnosis - based on the Whipple triad - is simple, however, it may be difficult to recognize in cases with near normal or only slightly elevated serum insulin levels, as well as in patients with known convulsive episodes. With the case presentation of an 81-year-old woman the authors draw attention to the pitfalls of the correct diagnosis. A special feature of the presented case is that convulsions persisted after surgical removal of the pancreatic neuroendocrine tumor verified with functional and imaging methods. Recurrant or residual tumor was not found, and morphological damage of the brain was absent. In the background of the continuing convulsions cerebrovascular alterations as well as the cytotoxic effect of the hypoglycemia-induced excessive glutamate production can be postulated.

Original languageHungarian
Pages (from-to)69-73
Number of pages5
JournalOrvosi Hetilap
Volume154
Issue number2
DOIs
Publication statusPublished - Jan 1 2013

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Insulinoma
Neuroendocrine Tumors
Seizures
Insulin
von Hippel-Lindau Disease
Multiple Endocrine Neoplasia Type 1
Glucose
Residual Neoplasm
Insulin-Secreting Cells
Serum
Hypoglycemia
Glutamic Acid
Brain
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Glükózszenzitív insulinoma mérsékelten emelkedett széruminzulinszinttel, eltávolítása után is fennmaradó epilepsziás rohamokkal. / Soós, Zsuzsanna; Czégeni, Anna; Salamon, Ferenc; Salamon, Mónika; Kenessey, I.; Folyovich, András; Tihanyi, Tibor; Winkler, G.

In: Orvosi Hetilap, Vol. 154, No. 2, 01.01.2013, p. 69-73.

Research output: Contribution to journalArticle

Soós, Zsuzsanna ; Czégeni, Anna ; Salamon, Ferenc ; Salamon, Mónika ; Kenessey, I. ; Folyovich, András ; Tihanyi, Tibor ; Winkler, G. / Glükózszenzitív insulinoma mérsékelten emelkedett széruminzulinszinttel, eltávolítása után is fennmaradó epilepsziás rohamokkal. In: Orvosi Hetilap. 2013 ; Vol. 154, No. 2. pp. 69-73.
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