A terhesség alatti hüvelyi natamycin-kezelés eset-kontroll teratológiai vizsgálata

Translated title of the contribution: A case-control teratological study of vaginal natamycin treatment during pregnancy

Zoltán Kazy, Péter Vargha, Endre Czeizel

Research output: Contribution to journalReview article

Abstract

The aim of this study was to investigate the teratogenicity of vaginal natamycin treatment during pregnancy. Data of human epidemiological studies have not been published so far. Pair analysis of cases with congenital anomalies and matched healthy controls was carried out. The population-based data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities between 1980 and 1996 included 38,151 pregnant women who delivered newborn infants without any congenital defects (control group) and 22,843 pregnant women who had fetuses or newborns with congenital abnormalities. 62 (0.27%) and 98 (0.26%) pregnant women were treated with natamycin in the case and the control group, respectively (crude OR 1.1 with 95% CI: 0.8-1.5). A teratogenic potential of vaginal natamycin treatment during the second and third months of pregnancy, the critical period for most major congenital abnormalities, was not indicated in the case-control pair analysis (adjusted OR 0.9 with 95% CI: 0.4-1.8). A somewhat higher mean birth weight (72 g) was found in the control newborn infants born to mothers who have had natamycin treatment as compared to the data of control newborn infants without this treatment (adjusted p=0.01), though the mean gestational age was shorter. From this study we may conclude that treatment with vaginal natamycin during pregnancy presents no detectable teratogenic risk for the fetus.

Translated title of the contributionA case-control teratological study of vaginal natamycin treatment during pregnancy
Original languageHungarian
Pages (from-to)219-224
Number of pages6
JournalMagyar Noorvosok Lapja
Volume67
Issue number4
Publication statusPublished - Aug 13 2004

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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