A case-control study of paternal and maternal age as risk factors in mood disorders

Konstantinos N. Fountoulakis, X. Gonda, Melina Siamouli, Panagiotis Panagiotidis, Katerina Moutou, Ioannis Nimatoudis, Siegfried Kasper

Research output: Contribution to journalArticle

Abstract

Objective: Advanced parental age might constitute a risk factor for various disorders. We tested whether this concerns also mood disorder patients. Methods: The study included 314 subjects (42 bipolar-BD patients; 21 manics and 21 depressives, 68 uni-polar-UD, and 204 normal controls-NC). Analysis of Covariance (ANCOVA) and the calculation of the Relative Risk (RR) and the Odds Ratio (OR) were used for the analysis. Results: Paternal age differed between NC and UD patients (29.42 ± 6.07 vs. 32.12 ± 5.54; p ¼.01) and manics (29.42 ± 6.07 vs. 35.00 ± 5.75; p ¼.001) and maternal age between NC and manics (25.46 ± 4.52 vs. 31.43 ± 4.75; p <.001) and manic and UD (31.43 ± 4.75 vs. 26.75 ± 6.03; p ¼.002). The RR and OR values suggested that advanced parental age constitutes a risk factor for the development of mood disorders. Conclusions: In a non-dose dependent and gender-independent, advanced parental age constitutes a risk factor for the development of BD with index episode of mania (probably manic predominant polar-ity); only advanced paternal age constitutes a risk factor for the development of UD and BD with index episode of depression (probably depressive predominant polarity). This is the first study suggesting differential effect of advanced parental age depending on predominant polarity of BD.

Original languageEnglish
JournalInternational Journal of Psychiatry in Clinical Practice
DOIs
Publication statusPublished - Jan 1 2019

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Paternal Age
Maternal Age
Mood Disorders
Case-Control Studies
Odds Ratio
Parents
Bipolar Disorder
Depression

Keywords

  • Bipolar disorder
  • Maternal age
  • Parental age
  • Paternal age
  • Unipolar depression

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

A case-control study of paternal and maternal age as risk factors in mood disorders. / Fountoulakis, Konstantinos N.; Gonda, X.; Siamouli, Melina; Panagiotidis, Panagiotis; Moutou, Katerina; Nimatoudis, Ioannis; Kasper, Siegfried.

In: International Journal of Psychiatry in Clinical Practice, 01.01.2019.

Research output: Contribution to journalArticle

Fountoulakis, Konstantinos N. ; Gonda, X. ; Siamouli, Melina ; Panagiotidis, Panagiotis ; Moutou, Katerina ; Nimatoudis, Ioannis ; Kasper, Siegfried. / A case-control study of paternal and maternal age as risk factors in mood disorders. In: International Journal of Psychiatry in Clinical Practice. 2019.
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AU - Nimatoudis, Ioannis

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AB - Objective: Advanced parental age might constitute a risk factor for various disorders. We tested whether this concerns also mood disorder patients. Methods: The study included 314 subjects (42 bipolar-BD patients; 21 manics and 21 depressives, 68 uni-polar-UD, and 204 normal controls-NC). Analysis of Covariance (ANCOVA) and the calculation of the Relative Risk (RR) and the Odds Ratio (OR) were used for the analysis. Results: Paternal age differed between NC and UD patients (29.42 ± 6.07 vs. 32.12 ± 5.54; p ¼.01) and manics (29.42 ± 6.07 vs. 35.00 ± 5.75; p ¼.001) and maternal age between NC and manics (25.46 ± 4.52 vs. 31.43 ± 4.75; p <.001) and manic and UD (31.43 ± 4.75 vs. 26.75 ± 6.03; p ¼.002). The RR and OR values suggested that advanced parental age constitutes a risk factor for the development of mood disorders. Conclusions: In a non-dose dependent and gender-independent, advanced parental age constitutes a risk factor for the development of BD with index episode of mania (probably manic predominant polar-ity); only advanced paternal age constitutes a risk factor for the development of UD and BD with index episode of depression (probably depressive predominant polarity). This is the first study suggesting differential effect of advanced parental age depending on predominant polarity of BD.

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