A case-control analysis of the teratogenic effects of co-trimoxazole

Research output: Contribution to journalArticle

35 Citations (Scopus)


The possible teratogenic effect of co-trimoxazole (sulfamethoxazole and trimethoprim, Bactrim® [Roche], Septrin® or Septra® [Burroughs-Wellcome], Sumetrolim® [EGIS]) was evaluated using the data set of the Hungarian Case-Control Surveillance of Congenital Anomalies. In the study period of 1980 through 1984, 1.25% of pregnant women who had healthy babies (negative control group) were treated with co-trimoxazole during pregnancy. In those who had babies with congenital anomalies the rate of co-trimoxazole use was 2.31%. The case-control analysis showed a significant increase of co-trimoxazole use only in the groups of cleft lip ± cleft palate and hypospadias. However, drug use was not higher during the critical period in either of the congenital anomaly groups. The distribution of component congenital anomalies in 13 cases affected by multiple congenital anomalies did not show any characteristic pattern. Respiratory and urinary system diseases were mentioned significantly more frequently in pregnancies of index patients' mothers. This analysis did not indicate any teratogenicity of co-trimoxazole. The higher drug use can probably be explained by maternal disorders.

Original languageEnglish
Pages (from-to)305-313
Number of pages9
JournalReproductive Toxicology
Issue number4
Publication statusPublished - 1990


  • case-control
  • co-trimoxazole
  • congenital anomaly surveillance
  • sulfamethoxazole
  • trimethoprim

ASJC Scopus subject areas

  • Toxicology

Fingerprint Dive into the research topics of 'A case-control analysis of the teratogenic effects of co-trimoxazole'. Together they form a unique fingerprint.

  • Cite this