A canine model of hyperdynamic sepsis induced by intestinal ischemia.

S. Nagy, K. Tárnoky, L. Tutsek, M. Borós, G. Karácsony

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A hyperdynamic sepsis model was developed in dogs. It is based on a 3-hour clamping of the arteries supplying the middle portion of the jejunum. The ensuing sepsis has a course of several days, during which the animals were studied in the conscious state. 2/3 of the animals developed a sustained 32-108 per cent increase in cardiac output, and survived 7 days or more. In the other 1/3 of the animals, the cardiac output was lower than the control value and all these animals died within 5 days. There were no differences between the two groups in other parameters examined. Sepsis caused a steady, slight decrease in mean arterial pressure, an increase in heart rate, and leukocytosis. The plasma levels of epinephrine and norepinephrine showed a sustained, significant elevation. The level of thromboxane B2 was high only on the first day of sepsis, and that of plasma renin activity on the first 2 days. Necrosis and edema of jejunal villi were demonstrated histologically in the early period. Hemocultures were positive in only 5 of 11 animals examined, suggesting the predominant role of absorbed toxins. This model simulates human sepsis well and is suitable for the study of pathophysiologic mechanisms in hyperdynamic sepsis.

Original languageEnglish
Pages (from-to)303-320
Number of pages18
JournalActa Physiologica Hungarica
Volume75
Issue number4
Publication statusPublished - 1990

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Canidae
Sepsis
Ischemia
Cardiac Output
Thromboxane B2
Leukocytosis
Jejunum
Renin
Constriction
Epinephrine
Edema
Norepinephrine
Arterial Pressure
Necrosis
Arteries
Heart Rate
Dogs

ASJC Scopus subject areas

  • Physiology

Cite this

A canine model of hyperdynamic sepsis induced by intestinal ischemia. / Nagy, S.; Tárnoky, K.; Tutsek, L.; Borós, M.; Karácsony, G.

In: Acta Physiologica Hungarica, Vol. 75, No. 4, 1990, p. 303-320.

Research output: Contribution to journalArticle

Nagy, S, Tárnoky, K, Tutsek, L, Borós, M & Karácsony, G 1990, 'A canine model of hyperdynamic sepsis induced by intestinal ischemia.', Acta Physiologica Hungarica, vol. 75, no. 4, pp. 303-320.
Nagy, S. ; Tárnoky, K. ; Tutsek, L. ; Borós, M. ; Karácsony, G. / A canine model of hyperdynamic sepsis induced by intestinal ischemia. In: Acta Physiologica Hungarica. 1990 ; Vol. 75, No. 4. pp. 303-320.
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