A Bisamide Derivative of [Mn(1,4-DO2A)] - Solution Thermodynamic, Kinetic, and NMR Relaxometric Studies

Attila Forgács, Lorenzo Tei, Z. Baranyai, Imre Tóth, László Zékány, Mauro Botta

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A new 1,4-DO2A-bisamide [1,4-DO2AM; 1,4-DO2A = 2,2′-(1,4,7,10-tetraazacyclododecane-1,4-diyl)diacetic acid] ligand was synthesized, and its MnII complex was prepared and investigated in detail by solution thermodynamic, kinetic, and 1H and 17O NMR relaxometric measurements. Although the stability constant of [Mn(1,4-DO2AM)]2+ (log KMnL = 12.64) is 2.5 log K units lower than that of [Mn(1,4-DO2A)], its kinetic inertness, investigated through its transmetallation reactions with Zn2+ ions, is much higher. In particular, the dissociation half-life (t1/2) of [Mn(1,4-DO2AM)]2+ is ten times higher than that of [Mn(1,4-DO2A)] (t1/2 = 556 vs. 49 h, pH 7.4). The longer rotational correlation time (τR = 53 ps) for [Mn(1,4-DO2AM)]2+ is mainly responsible for the slightly higher (+20 %) relaxivity (r1 = 2.5 mM-1 s-1, 20 MHz, 25 °C) with respect to that of [Mn(1,4-DO2A)]. Notably, the water exchange rate of the coordinated water molecule is one order of magnitude slower than that of [Mn(1,4-DO2A)] (298kex = 115 ± 6 × 106 s-1). Finally, the dynamic properties of [Zn(1,4-DO2AM)] were investigated by NMR spectroscopy, and the decoordination and arm-rotation processes of the acetamide pendant arms were followed.

Original languageEnglish
Pages (from-to)1165-1174
Number of pages10
JournalEuropean Journal of Inorganic Chemistry
Volume2016
Issue number8
DOIs
Publication statusPublished - Mar 1 2016

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Nuclear magnetic resonance
Thermodynamics
Derivatives
Kinetics
Water
Nuclear magnetic resonance spectroscopy
Ions
Ligands
Molecules
Acids
acetamide
cyclen

Keywords

  • Imaging agents
  • Kinetics
  • Macrocyclic ligands
  • Magnetic resonance imaging
  • Manganese

ASJC Scopus subject areas

  • Inorganic Chemistry

Cite this

A Bisamide Derivative of [Mn(1,4-DO2A)] - Solution Thermodynamic, Kinetic, and NMR Relaxometric Studies. / Forgács, Attila; Tei, Lorenzo; Baranyai, Z.; Tóth, Imre; Zékány, László; Botta, Mauro.

In: European Journal of Inorganic Chemistry, Vol. 2016, No. 8, 01.03.2016, p. 1165-1174.

Research output: Contribution to journalArticle

Forgács, Attila ; Tei, Lorenzo ; Baranyai, Z. ; Tóth, Imre ; Zékány, László ; Botta, Mauro. / A Bisamide Derivative of [Mn(1,4-DO2A)] - Solution Thermodynamic, Kinetic, and NMR Relaxometric Studies. In: European Journal of Inorganic Chemistry. 2016 ; Vol. 2016, No. 8. pp. 1165-1174.
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AU - Zékány, László

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AB - A new 1,4-DO2A-bisamide [1,4-DO2AM; 1,4-DO2A = 2,2′-(1,4,7,10-tetraazacyclododecane-1,4-diyl)diacetic acid] ligand was synthesized, and its MnII complex was prepared and investigated in detail by solution thermodynamic, kinetic, and 1H and 17O NMR relaxometric measurements. Although the stability constant of [Mn(1,4-DO2AM)]2+ (log KMnL = 12.64) is 2.5 log K units lower than that of [Mn(1,4-DO2A)], its kinetic inertness, investigated through its transmetallation reactions with Zn2+ ions, is much higher. In particular, the dissociation half-life (t1/2) of [Mn(1,4-DO2AM)]2+ is ten times higher than that of [Mn(1,4-DO2A)] (t1/2 = 556 vs. 49 h, pH 7.4). The longer rotational correlation time (τR = 53 ps) for [Mn(1,4-DO2AM)]2+ is mainly responsible for the slightly higher (+20 %) relaxivity (r1 = 2.5 mM-1 s-1, 20 MHz, 25 °C) with respect to that of [Mn(1,4-DO2A)]. Notably, the water exchange rate of the coordinated water molecule is one order of magnitude slower than that of [Mn(1,4-DO2A)] (298kex = 115 ± 6 × 106 s-1). Finally, the dynamic properties of [Zn(1,4-DO2AM)] were investigated by NMR spectroscopy, and the decoordination and arm-rotation processes of the acetamide pendant arms were followed.

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KW - Magnetic resonance imaging

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