A bis(3-hydroxy-4-pyridinone)-EDTA derivative as a strong chelator for M3+ hard metal ions: Complexation ability and selectivity

Sofia Gama, Paul Dron, Silvia Chaves, E. Farkas, M. Amélia Santos

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The study of chelating compounds is very important to solve problems related to human metal overload. 3-Hydroxy-3-pyridinones (HP), namely deferiprone, have been clinically used for chelating therapy of Fe and Al over the last decade. A multi-disciplinary search for alternative molecules led us to develop poly-(3-hydroxy-4-pyridinones) to increase metal chelation efficacy. We present herein a complexation study of a new bis-(3-hydroxy-4-pyridinone)-EDTA derivative with a set of M3+ hard metal ions (M = Fe, Al, Ga), as well as Zn2+, a biologically relevant metal ion. Thus a systematic aqueous solution equilibrium study was performed using potentiometric and spectroscopic techniques (UV-Vis, NMR methods). These set of results enables the establishment of specific models as well as the determination of thermodynamic stability constants and coordination modes of the metal complexes. The results indicate that this ligand has a higher affinity for chelating to these hard metal ions than deferiprone, and that the coordination occurs mostly through the HP moieties. Furthermore, it was also found that this ligand has a higher selectivity for chelating to M3+ hard metal ions (M = Fe, Al, Ga) than Zn2+.

Original languageEnglish
Pages (from-to)6141-6150
Number of pages10
JournalJournal of the Chemical Society. Dalton Transactions
Issue number31
DOIs
Publication statusPublished - Jul 28 2009

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Pyridones
Chelating Agents
Chelation
Complexation
Edetic Acid
Metal ions
Derivatives
Metals
Ligands
Coordination Complexes
Thermodynamic stability
Nuclear magnetic resonance
hard metal
Molecules

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

A bis(3-hydroxy-4-pyridinone)-EDTA derivative as a strong chelator for M3+ hard metal ions : Complexation ability and selectivity. / Gama, Sofia; Dron, Paul; Chaves, Silvia; Farkas, E.; Santos, M. Amélia.

In: Journal of the Chemical Society. Dalton Transactions, No. 31, 28.07.2009, p. 6141-6150.

Research output: Contribution to journalArticle

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