We introduce a simple nonlinear dynamic tumor growth model which distinguishes between a core and a peripherial compartment, and accounts for nutrient and congestion-dependent cell proliferation, necrosis and volume growth. The model synthesis procedure considers that later the model shall be extended with mechanisms describing angiogenesis and will be used in control based optimization of anti-angiogenic treatment procedures.
- Biomedical systems
- Concentrated-parameter models
- Systems biology
- Tumor growth modelling
ASJC Scopus subject areas
- Control and Systems Engineering