A bicompartmental dynamic tumor growth model

Dávid Csercsik, Johanna Sápi, L. Kovács

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We introduce a simple nonlinear dynamic tumor growth model which distinguishes between a core and a peripherial compartment, and accounts for nutrient and congestion-dependent cell proliferation, necrosis and volume growth. The model synthesis procedure considers that later the model shall be extended with mechanisms describing angiogenesis and will be used in control based optimization of anti-angiogenic treatment procedures.

Original languageEnglish
Pages (from-to)12216-12221
Number of pages6
JournalIFAC-PapersOnLine
Volume50
Issue number1
DOIs
Publication statusPublished - Jul 1 2017

Fingerprint

Tumors
Cell proliferation
Nutrients

Keywords

  • Biomedical systems
  • Concentrated-parameter models
  • Simulations
  • Systems biology
  • Tumor growth modelling

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

A bicompartmental dynamic tumor growth model. / Csercsik, Dávid; Sápi, Johanna; Kovács, L.

In: IFAC-PapersOnLine, Vol. 50, No. 1, 01.07.2017, p. 12216-12221.

Research output: Contribution to journalArticle

Csercsik, Dávid ; Sápi, Johanna ; Kovács, L. / A bicompartmental dynamic tumor growth model. In: IFAC-PapersOnLine. 2017 ; Vol. 50, No. 1. pp. 12216-12221.
@article{5a84c948d4c7455a909b7f116af6b31e,
title = "A bicompartmental dynamic tumor growth model",
abstract = "We introduce a simple nonlinear dynamic tumor growth model which distinguishes between a core and a peripherial compartment, and accounts for nutrient and congestion-dependent cell proliferation, necrosis and volume growth. The model synthesis procedure considers that later the model shall be extended with mechanisms describing angiogenesis and will be used in control based optimization of anti-angiogenic treatment procedures.",
keywords = "Biomedical systems, Concentrated-parameter models, Simulations, Systems biology, Tumor growth modelling",
author = "D{\'a}vid Csercsik and Johanna S{\'a}pi and L. Kov{\'a}cs",
year = "2017",
month = "7",
day = "1",
doi = "10.1016/j.ifacol.2017.08.2119",
language = "English",
volume = "50",
pages = "12216--12221",
journal = "IFAC-PapersOnLine",
issn = "2405-8963",
publisher = "IFAC Secretariat",
number = "1",

}

TY - JOUR

T1 - A bicompartmental dynamic tumor growth model

AU - Csercsik, Dávid

AU - Sápi, Johanna

AU - Kovács, L.

PY - 2017/7/1

Y1 - 2017/7/1

N2 - We introduce a simple nonlinear dynamic tumor growth model which distinguishes between a core and a peripherial compartment, and accounts for nutrient and congestion-dependent cell proliferation, necrosis and volume growth. The model synthesis procedure considers that later the model shall be extended with mechanisms describing angiogenesis and will be used in control based optimization of anti-angiogenic treatment procedures.

AB - We introduce a simple nonlinear dynamic tumor growth model which distinguishes between a core and a peripherial compartment, and accounts for nutrient and congestion-dependent cell proliferation, necrosis and volume growth. The model synthesis procedure considers that later the model shall be extended with mechanisms describing angiogenesis and will be used in control based optimization of anti-angiogenic treatment procedures.

KW - Biomedical systems

KW - Concentrated-parameter models

KW - Simulations

KW - Systems biology

KW - Tumor growth modelling

UR - http://www.scopus.com/inward/record.url?scp=85044279852&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044279852&partnerID=8YFLogxK

U2 - 10.1016/j.ifacol.2017.08.2119

DO - 10.1016/j.ifacol.2017.08.2119

M3 - Article

AN - SCOPUS:85044279852

VL - 50

SP - 12216

EP - 12221

JO - IFAC-PapersOnLine

JF - IFAC-PapersOnLine

SN - 2405-8963

IS - 1

ER -