A 30 KB region of the Epstein-Barr virus genome is colinear with the rearranged human immunoglobulin gene loci

Implications for a "ping-pong evolution" model for persisting viruses and their hosts: A review

H. H. Niller, D. Salamon, S. Rahmann, Karin Ilg, Anita Koroknai, F. Bánáti, F. Schwarzmann, H. Wolf, J. Minárovits

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The left part of the Epstein-Barr virus (EBV) genome exhibits a strong coli-nearity of structural and functional elements with the immunoglobulin (Ig) gene loci which is only partially reflected in nucleotide sequence homologies. We propose that this colinearity may be the result of an inter-dependent co-evolution of the immunoglobulin loci together with EBV. Our observation could help elucidating the mechanisms of somatic hypermutation, explaining the ability of EBV to accidentally cause tumors, and shedding more light on the general mechanisms of viral and organismal evolution. We suggest that persisting viruses served as a complement for the organismal germline like in a ping-pong game and outline The Ping-Pong Evolution Hypothesis.

Original languageEnglish
Pages (from-to)469-484
Number of pages16
JournalActa Microbiologica et Immunologica Hungarica
Volume51
Issue number4
DOIs
Publication statusPublished - 2004

Fingerprint

Immunoglobulin Genes
Human Herpesvirus 4
Genome
Viruses
Sequence Homology
Immunoglobulins
Observation
Neoplasms

Keywords

  • c-Myc oncogene
  • Epstein-Barr virus
  • Germline complement
  • Herpesviruses
  • Immunoglobulin genes
  • Ping-pong evolution
  • Somatic hypermutation

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Medicine(all)
  • Microbiology

Cite this

A 30 KB region of the Epstein-Barr virus genome is colinear with the rearranged human immunoglobulin gene loci : Implications for a "ping-pong evolution" model for persisting viruses and their hosts: A review. / Niller, H. H.; Salamon, D.; Rahmann, S.; Ilg, Karin; Koroknai, Anita; Bánáti, F.; Schwarzmann, F.; Wolf, H.; Minárovits, J.

In: Acta Microbiologica et Immunologica Hungarica, Vol. 51, No. 4, 2004, p. 469-484.

Research output: Contribution to journalArticle

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