98% Enantioselectivity in the asymmetric synthesis of a useful chiral building block by heterogeneous method: Enantioselective hydrogenation of ethyl-benzoylformate over cinchona modified Pt/Al2O3 catalysts in the acetic acid

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Abstract

Extremely high (98%) enantioselectivity of the hydrogenation of ethyl benzoylformate on Pt/Al2O3 modified with dihydrocinchonidine was achieved. The difference between the rates of racemic and enantioselective hydrogenation was less significant than in the case of ethyl pyruvate. This indicates that ligand acceleration is a welcome effect but no necessary prerequisite for achieving high enantioselectivity.

Original languageEnglish
Pages (from-to)125-127
Number of pages3
JournalCatalysis Communications
Volume3
Issue number3
DOIs
Publication statusPublished - Mar 1 2002

Keywords

  • Dihydrocinchonidine
  • Enantioselective
  • Ethyl-(R)-mandalete
  • Ethyl-benzoylformate
  • Hydrogenation
  • Pt/AlO

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Process Chemistry and Technology

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