Extremely high (98%) enantioselectivity of the hydrogenation of ethyl benzoylformate on Pt/Al2O3 modified with dihydrocinchonidine was achieved. The difference between the rates of racemic and enantioselective hydrogenation was less significant than in the case of ethyl pyruvate. This indicates that ligand acceleration is a welcome effect but no necessary prerequisite for achieving high enantioselectivity.
ASJC Scopus subject areas
- Process Chemistry and Technology