98% Enantioselectivity in the asymmetric synthesis of a useful chiral building block by heterogeneous method: Enantioselective hydrogenation of ethyl-benzoylformate over cinchona modified Pt/Al2O3 catalysts in the acetic acid

Mária A. Sutyinszki, K. Szöri, K. Felföldi, M. Bartók

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Extremely high (98%) enantioselectivity of the hydrogenation of ethyl benzoylformate on Pt/Al2O3 modified with dihydrocinchonidine was achieved. The difference between the rates of racemic and enantioselective hydrogenation was less significant than in the case of ethyl pyruvate. This indicates that ligand acceleration is a welcome effect but no necessary prerequisite for achieving high enantioselectivity.

Original languageEnglish
Pages (from-to)125-127
Number of pages3
JournalCatalysis Communications
Volume3
Issue number3
DOIs
Publication statusPublished - Mar 2002

Fingerprint

Cinchona
Enantioselectivity
Acetic acid
Acetic Acid
Hydrogenation
Catalysts
Ligands
phenylglyoxylic acid

Keywords

  • Dihydrocinchonidine
  • Enantioselective
  • Ethyl-(R)-mandalete
  • Ethyl-benzoylformate
  • Hydrogenation
  • Pt/AlO

ASJC Scopus subject areas

  • Catalysis
  • Process Chemistry and Technology

Cite this

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title = "98{\%} Enantioselectivity in the asymmetric synthesis of a useful chiral building block by heterogeneous method: Enantioselective hydrogenation of ethyl-benzoylformate over cinchona modified Pt/Al2O3 catalysts in the acetic acid",
abstract = "Extremely high (98{\%}) enantioselectivity of the hydrogenation of ethyl benzoylformate on Pt/Al2O3 modified with dihydrocinchonidine was achieved. The difference between the rates of racemic and enantioselective hydrogenation was less significant than in the case of ethyl pyruvate. This indicates that ligand acceleration is a welcome effect but no necessary prerequisite for achieving high enantioselectivity.",
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T1 - 98% Enantioselectivity in the asymmetric synthesis of a useful chiral building block by heterogeneous method

T2 - Enantioselective hydrogenation of ethyl-benzoylformate over cinchona modified Pt/Al2O3 catalysts in the acetic acid

AU - Sutyinszki, Mária A.

AU - Szöri, K.

AU - Felföldi, K.

AU - Bartók, M.

PY - 2002/3

Y1 - 2002/3

N2 - Extremely high (98%) enantioselectivity of the hydrogenation of ethyl benzoylformate on Pt/Al2O3 modified with dihydrocinchonidine was achieved. The difference between the rates of racemic and enantioselective hydrogenation was less significant than in the case of ethyl pyruvate. This indicates that ligand acceleration is a welcome effect but no necessary prerequisite for achieving high enantioselectivity.

AB - Extremely high (98%) enantioselectivity of the hydrogenation of ethyl benzoylformate on Pt/Al2O3 modified with dihydrocinchonidine was achieved. The difference between the rates of racemic and enantioselective hydrogenation was less significant than in the case of ethyl pyruvate. This indicates that ligand acceleration is a welcome effect but no necessary prerequisite for achieving high enantioselectivity.

KW - Dihydrocinchonidine

KW - Enantioselective

KW - Ethyl-(R)-mandalete

KW - Ethyl-benzoylformate

KW - Hydrogenation

KW - Pt/AlO

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