8. Radiosurgical pathology of brain tumors: Metastases, schwannomas, meningiomas, astrocytomas, hemangioblastomas

G. Szeifert, D. Kondziolka, D. Atteberry, I. Salmon, S. Rorive, M. Levivier, L. Lunsford

Research output: Chapter in Book/Report/Conference proceedingChapter

15 Citations (Scopus)

Abstract

Systematic human pathological background to brain tumor radiosurgery explaining biological and pathophysiological effects of focused irradiation barely exists. The goal of this study was to explore histopathological changes evoked by single high-dose irradiation in a set of different brain tumors following Gamma Knife radiosurgery (GKRS). Light microscopy revealed that GKRS evokes degenerative and proliferative pathological changes in the parenchyma, stroma and vessels of the irradiated tumors. Three main histological types of gamma radiolesions, that is acute, subacute and chronic variants of tissue reactions were recognized in different neoplasms irrespective of their ontogenetic nature. Acute type gamma radiolesions were characterized mainly with necrotic changes and appeared either early or in a delayed time interval. Subacute type gamma radiolesions expressed resorptive activity also with early or delayed chronology. Chronic type lesions showed a reparative tendency but presented only at the delayed stage. These changes seem to follow each other consecutively. There was no significant relation between morphological characteristics of the generated tissue reaction and the time interval elapsed after GKRS. This relative time and environment autonomy of the developed pathological lesions with similar histological picture in different neoplasms suggests either a vascular mechanism or/and a genetically directed origin presumably induced by the ionizing energy of high-dose irradiation.

Original languageEnglish
Title of host publicationProgress in Neurological Surgery
Pages91-105
Number of pages15
Volume20
DOIs
Publication statusPublished - 2007

Publication series

NameProgress in Neurological Surgery
Volume20
ISSN (Print)00796492
ISSN (Electronic)16623924

Fingerprint

Hemangioblastoma
Radiosurgery
Neurilemmoma
Astrocytoma
Meningioma
Brain Neoplasms
Pathology
Neoplasm Metastasis
Chronology
Neoplasms
Blood Vessels
Microscopy
Light

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Medicine(all)

Cite this

Szeifert, G., Kondziolka, D., Atteberry, D., Salmon, I., Rorive, S., Levivier, M., & Lunsford, L. (2007). 8. Radiosurgical pathology of brain tumors: Metastases, schwannomas, meningiomas, astrocytomas, hemangioblastomas. In Progress in Neurological Surgery (Vol. 20, pp. 91-105). (Progress in Neurological Surgery; Vol. 20). https://doi.org/10.1159/000100098

8. Radiosurgical pathology of brain tumors : Metastases, schwannomas, meningiomas, astrocytomas, hemangioblastomas. / Szeifert, G.; Kondziolka, D.; Atteberry, D.; Salmon, I.; Rorive, S.; Levivier, M.; Lunsford, L.

Progress in Neurological Surgery. Vol. 20 2007. p. 91-105 (Progress in Neurological Surgery; Vol. 20).

Research output: Chapter in Book/Report/Conference proceedingChapter

Szeifert, G, Kondziolka, D, Atteberry, D, Salmon, I, Rorive, S, Levivier, M & Lunsford, L 2007, 8. Radiosurgical pathology of brain tumors: Metastases, schwannomas, meningiomas, astrocytomas, hemangioblastomas. in Progress in Neurological Surgery. vol. 20, Progress in Neurological Surgery, vol. 20, pp. 91-105. https://doi.org/10.1159/000100098
Szeifert G, Kondziolka D, Atteberry D, Salmon I, Rorive S, Levivier M et al. 8. Radiosurgical pathology of brain tumors: Metastases, schwannomas, meningiomas, astrocytomas, hemangioblastomas. In Progress in Neurological Surgery. Vol. 20. 2007. p. 91-105. (Progress in Neurological Surgery). https://doi.org/10.1159/000100098
Szeifert, G. ; Kondziolka, D. ; Atteberry, D. ; Salmon, I. ; Rorive, S. ; Levivier, M. ; Lunsford, L. / 8. Radiosurgical pathology of brain tumors : Metastases, schwannomas, meningiomas, astrocytomas, hemangioblastomas. Progress in Neurological Surgery. Vol. 20 2007. pp. 91-105 (Progress in Neurological Surgery).
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