8-OH-DPAT and MK-801 affect epileptic activity independently of vigilance

Janos Filakovszky, Sandor Kantor, Peter Halasz, Gyorgy Bagdy

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Vigilance and parallel occurrence of epileptic activity after administration of the 5-HT1A agonist 8-OH-DPAT and the NMDA receptor antagonist MK-801 were studied in the genetic absence epilepsy model WAG/Rij rats. Spike-wave discharges (SWD) were present predominantly in passive awake and light slow wave sleep (SWS1) either in control animals or after treatments. Injection of 8-OH-DPAT (20.0 μg/rat i.c.v.) caused marked increase and MK-801 (10.0 μg/rat i.c.v.) decrease in SWD densities, thus the ratios of SWD in passive awake and in SWS1. SWD densities of MK-801 plus 8-OH-DPAT in combination were similar to those of CSF + CSF treated control rats. Both 8-OH-DPAT and MK-801 transiently increased the duration of active awake, increased latency and decreased duration of rapid eye movement (REM) sleep. 8-OH-DPAT increased the amount of SWD despite the decrease in the duration of SWS1. MK-801 decreased the amount of SWD despite the lack of significant change in duration of passive awake or SWS1. Pre-treatment with MK-801 reversed 8-OH-DPAT - induced increase in duration of SWD without any effect on 8-OH-DPAT-induced changes in sleep parameters. Our studies provide evidence that 8-OH-DPAT-induced epileptic activity is independent of its effect on sleep, and that interaction of serotonergic and glutamatergic systems plays a role in the generation of SWD, but not in the regulation of vigilance and sleep.

Original languageEnglish
Pages (from-to)551-556
Number of pages6
JournalNeurochemistry international
Volume38
Issue number7
DOIs
Publication statusPublished - Jun 1 2001

Keywords

  • (+)-5-methyl-10,11-dihydro-5H-dibenzo (a,d) cyclohepten-5,10-imine maleate (MK-801)
  • 5-HT receptor
  • Absence epilepsy
  • Glutamate
  • NMDA receptor
  • Serotonin, 8-hydroxy-2-(di-n-propylamino)-tetralin hydrobromide (8-OH-DPAT)
  • Sleep
  • Spike -Wave discharge
  • WAG/RIJ rats

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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