7-oxo-PGI2 induced late appearing and long lasting antiischaemic and antiarrhythmic action in dogs

A. Végh, E. Udvary, L. Szekeres, Z. Szilvássy

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In our earlier experiments administration of the stable PGI2 analogue: 7-oxo-PGI2-ephedrine salt to dogs resulted in a late-appearing and long-lasting protection from coronary ligation induced ischaemia as well as from postocclusion and reperfusion arrhythmias. Objective of the present study was to evaluate the extent and duration of antiischaemic and antiarrhythmic action induced by a single dose 50 ug/kg i.m. 7-oxo-PGI2 in dogs subjected to myocardial ischaemia evoked by left anterior descending coronary artery (LAD) ligation at different intervals (2, 6, 24, 48, 72 hours and 2 weeks) after treatment. After anaesthesia and thoracotomy the electrophysiological parameters - sinus cycle length (SCL), corrected sinus node recovery time (CSNRT), atrial and ventricular functional refractory period (AFRP, VFRP), and atrio-ventricular effective refractory period (A-V ERP) - were determined by means of computer controlled programmed electrical stimulation. Then the animals were subjected to LAD occlusion for 25 minutes and subsequent reperfusion. 7-oxo-PGI2 pretreatment considerably protected against myocardial ischaemia i.e. there was significant reduction in ST-segment elevation, the number of extrasystoles (ES) and the incidence of ventricular fibrillation (VF). The antiischaemic action started 2 or 6 hours after the drug administration, however, the maximal protection - indicated by the diminution of ischaemic epicardial ST-segment elevation - as well as the most striking reduction in postocclusion and reperfusion arrhythmias could be observed 48 hours after the single dose of 7-oxo-PGI2 and in case of two weeks treatment. In these groups the incidence of VF was markedly reduced compared with the control group. In both groups CSNRT has shown the most expressed prolongation, however, AFRP and to lesser degree VFRP were also prolonged.

Original languageEnglish
JournalBiomedica Biochimica Acta
Volume47
Issue number10-11
Publication statusPublished - 1988

Fingerprint

Epoprostenol
Dogs
Reperfusion
Sinoatrial Node
Ventricular Fibrillation
Refractory materials
Myocardial Ischemia
Ligation
Cardiac Arrhythmias
Premature Cardiac Complexes
Recovery
Ephedrine
Incidence
Thoracotomy
Electric Stimulation
Coronary Vessels
Animals
Ischemia
Anesthesia
Salts

ASJC Scopus subject areas

  • Biochemistry

Cite this

7-oxo-PGI2 induced late appearing and long lasting antiischaemic and antiarrhythmic action in dogs. / Végh, A.; Udvary, E.; Szekeres, L.; Szilvássy, Z.

In: Biomedica Biochimica Acta, Vol. 47, No. 10-11, 1988.

Research output: Contribution to journalArticle

@article{ad2a5053b8374216b4e1c64c5f6f14af,
title = "7-oxo-PGI2 induced late appearing and long lasting antiischaemic and antiarrhythmic action in dogs",
abstract = "In our earlier experiments administration of the stable PGI2 analogue: 7-oxo-PGI2-ephedrine salt to dogs resulted in a late-appearing and long-lasting protection from coronary ligation induced ischaemia as well as from postocclusion and reperfusion arrhythmias. Objective of the present study was to evaluate the extent and duration of antiischaemic and antiarrhythmic action induced by a single dose 50 ug/kg i.m. 7-oxo-PGI2 in dogs subjected to myocardial ischaemia evoked by left anterior descending coronary artery (LAD) ligation at different intervals (2, 6, 24, 48, 72 hours and 2 weeks) after treatment. After anaesthesia and thoracotomy the electrophysiological parameters - sinus cycle length (SCL), corrected sinus node recovery time (CSNRT), atrial and ventricular functional refractory period (AFRP, VFRP), and atrio-ventricular effective refractory period (A-V ERP) - were determined by means of computer controlled programmed electrical stimulation. Then the animals were subjected to LAD occlusion for 25 minutes and subsequent reperfusion. 7-oxo-PGI2 pretreatment considerably protected against myocardial ischaemia i.e. there was significant reduction in ST-segment elevation, the number of extrasystoles (ES) and the incidence of ventricular fibrillation (VF). The antiischaemic action started 2 or 6 hours after the drug administration, however, the maximal protection - indicated by the diminution of ischaemic epicardial ST-segment elevation - as well as the most striking reduction in postocclusion and reperfusion arrhythmias could be observed 48 hours after the single dose of 7-oxo-PGI2 and in case of two weeks treatment. In these groups the incidence of VF was markedly reduced compared with the control group. In both groups CSNRT has shown the most expressed prolongation, however, AFRP and to lesser degree VFRP were also prolonged.",
author = "A. V{\'e}gh and E. Udvary and L. Szekeres and Z. Szilv{\'a}ssy",
year = "1988",
language = "English",
volume = "47",
journal = "Biomedica Biochimica Acta",
issn = "0232-766X",
publisher = "Akademie Verlag GMBH",
number = "10-11",

}

TY - JOUR

T1 - 7-oxo-PGI2 induced late appearing and long lasting antiischaemic and antiarrhythmic action in dogs

AU - Végh, A.

AU - Udvary, E.

AU - Szekeres, L.

AU - Szilvássy, Z.

PY - 1988

Y1 - 1988

N2 - In our earlier experiments administration of the stable PGI2 analogue: 7-oxo-PGI2-ephedrine salt to dogs resulted in a late-appearing and long-lasting protection from coronary ligation induced ischaemia as well as from postocclusion and reperfusion arrhythmias. Objective of the present study was to evaluate the extent and duration of antiischaemic and antiarrhythmic action induced by a single dose 50 ug/kg i.m. 7-oxo-PGI2 in dogs subjected to myocardial ischaemia evoked by left anterior descending coronary artery (LAD) ligation at different intervals (2, 6, 24, 48, 72 hours and 2 weeks) after treatment. After anaesthesia and thoracotomy the electrophysiological parameters - sinus cycle length (SCL), corrected sinus node recovery time (CSNRT), atrial and ventricular functional refractory period (AFRP, VFRP), and atrio-ventricular effective refractory period (A-V ERP) - were determined by means of computer controlled programmed electrical stimulation. Then the animals were subjected to LAD occlusion for 25 minutes and subsequent reperfusion. 7-oxo-PGI2 pretreatment considerably protected against myocardial ischaemia i.e. there was significant reduction in ST-segment elevation, the number of extrasystoles (ES) and the incidence of ventricular fibrillation (VF). The antiischaemic action started 2 or 6 hours after the drug administration, however, the maximal protection - indicated by the diminution of ischaemic epicardial ST-segment elevation - as well as the most striking reduction in postocclusion and reperfusion arrhythmias could be observed 48 hours after the single dose of 7-oxo-PGI2 and in case of two weeks treatment. In these groups the incidence of VF was markedly reduced compared with the control group. In both groups CSNRT has shown the most expressed prolongation, however, AFRP and to lesser degree VFRP were also prolonged.

AB - In our earlier experiments administration of the stable PGI2 analogue: 7-oxo-PGI2-ephedrine salt to dogs resulted in a late-appearing and long-lasting protection from coronary ligation induced ischaemia as well as from postocclusion and reperfusion arrhythmias. Objective of the present study was to evaluate the extent and duration of antiischaemic and antiarrhythmic action induced by a single dose 50 ug/kg i.m. 7-oxo-PGI2 in dogs subjected to myocardial ischaemia evoked by left anterior descending coronary artery (LAD) ligation at different intervals (2, 6, 24, 48, 72 hours and 2 weeks) after treatment. After anaesthesia and thoracotomy the electrophysiological parameters - sinus cycle length (SCL), corrected sinus node recovery time (CSNRT), atrial and ventricular functional refractory period (AFRP, VFRP), and atrio-ventricular effective refractory period (A-V ERP) - were determined by means of computer controlled programmed electrical stimulation. Then the animals were subjected to LAD occlusion for 25 minutes and subsequent reperfusion. 7-oxo-PGI2 pretreatment considerably protected against myocardial ischaemia i.e. there was significant reduction in ST-segment elevation, the number of extrasystoles (ES) and the incidence of ventricular fibrillation (VF). The antiischaemic action started 2 or 6 hours after the drug administration, however, the maximal protection - indicated by the diminution of ischaemic epicardial ST-segment elevation - as well as the most striking reduction in postocclusion and reperfusion arrhythmias could be observed 48 hours after the single dose of 7-oxo-PGI2 and in case of two weeks treatment. In these groups the incidence of VF was markedly reduced compared with the control group. In both groups CSNRT has shown the most expressed prolongation, however, AFRP and to lesser degree VFRP were also prolonged.

UR - http://www.scopus.com/inward/record.url?scp=0024244695&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024244695&partnerID=8YFLogxK

M3 - Article

VL - 47

JO - Biomedica Biochimica Acta

JF - Biomedica Biochimica Acta

SN - 0232-766X

IS - 10-11

ER -