6,12-Dihydro-1-benzopyrano [3,4-b] [1,4] benzothiazin-6-ones: Synthesis and mdr reversal in tumor cells

Anamik Shah, Yogesh Naliapara, Dinesh Sureja, Noboru Motohashi, Masami Kawase, Csilla Miskolci, Diana Szabo, Joseph Molnár

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Six 6,12-dihydro-1-benzopyrano[3,4-b][1,4]benzothiazin-6-ones and three coumarins were systematically investigated for reversal of multidrug resistance of bacteria and cancer cells in model experiments. 7-Methylcoumarin was able to eliminate the E. coli plasmid significantly; however, the other derivatives were ineffective. Four of 6,12-dihydro-1-benzopyrano[3,4-b][1,4] benzothiazin-6-ones had a moderate effect on the multidrug resistance efflux pump of mouse lymphoma cells in vitro. Despite of the similarity of resistance mechanisms of bacteria and turner cells, the reversal of drug resistance in bacteria and in cancer cells is not uniform because the structure- activity requirements are apparently different.

Original languageEnglish
Pages (from-to)3001-3004
Number of pages4
JournalAnticancer research
Issue number4 C
Publication statusPublished - Jul 1 1998



  • 6,12-Dihydro-1-benzopyrano[3,4-b][1,4]benzothiazin-6-ones
  • mdr reversal on tumor cells

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Shah, A., Naliapara, Y., Sureja, D., Motohashi, N., Kawase, M., Miskolci, C., Szabo, D., & Molnár, J. (1998). 6,12-Dihydro-1-benzopyrano [3,4-b] [1,4] benzothiazin-6-ones: Synthesis and mdr reversal in tumor cells. Anticancer research, 18(4 C), 3001-3004.