4-Sulfonatocalixarene-induced nanoparticle formation of methylimidazolium-conjugated dextrans

Utilization for drug encapsulation

Véronique Wintgens, Jean Michel Guigner, Z. Miskolczy, Catherine Amiel, L. Biczók

Research output: Contribution to journalArticle

Abstract

Methylimidazolium side groups were grafted via ether linkage to dextran and the self-assembly of these polymers with 4-sulfonato-calix[n]arenes (SCXn) was studied in aqueous solutions. Dynamic light scattering and zeta potential measurements revealed the mixing ratio ranges of the constituents where stable nanoparticles could be created. The macrocycle size of SCXn and the molecular mass of the polymer barely affected the nanoparticle diameter, but the lowering of the imidazolium degree of substitution substantially diminished the stability of the associates. The pH change from neutral to acidic also unfavourably influenced the self-organization owing mainly to the decrease of the SCXn charge. Cryogenic transmission electron microscopy images proved the spherical morphology of the nanoproducts in which the stoichiometry of the constituents was always close to the one corresponding to charge compensation. The flexible and positively charged dextran-chains are compacted by the polyanionic SCXn. Coralyne, a pharmacologically important alkaloid was efficiently embedded by self-assembly in the produced nanoparticles reaching 99% association efficiency.

Original languageEnglish
Article number115071
JournalCarbohydrate Polymers
Volume223
DOIs
Publication statusPublished - Nov 1 2019

Fingerprint

Calixarenes
Dextran
Dextrans
Encapsulation
Nanoparticles
Self assembly
coralyne
Pharmaceutical Preparations
Alkaloids
Polymers
Molecular mass
Dynamic light scattering
Zeta potential
Stoichiometry
Cryogenics
Ethers
Substitution reactions
Association reactions
Ether
Transmission electron microscopy

Keywords

  • Alkaloid
  • Cationic polymer
  • Drug delivery
  • Macrocycle
  • Self-assembly

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

Cite this

4-Sulfonatocalixarene-induced nanoparticle formation of methylimidazolium-conjugated dextrans : Utilization for drug encapsulation. / Wintgens, Véronique; Guigner, Jean Michel; Miskolczy, Z.; Amiel, Catherine; Biczók, L.

In: Carbohydrate Polymers, Vol. 223, 115071, 01.11.2019.

Research output: Contribution to journalArticle

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