3,4-metilén-dioxi-pirovaleron-(MDPV-) epidémia?

Translated title of the contribution: 3,4-methylene-dioxy-pyrovalerone (MDPV) epidemic?

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Little is known about 3,4-methylene-dioxy-pyrovalerone (MDPV), a new designer drug that has become popular in Hungary in the last couple of months. At the same time, its consumption as a consequence of its low street-price rises so fast that the event can be considered as an epidemic. This paper reviews the chemistry, biochemistry and metabolism of MDPV, then, on the basis of few international reports and clinical observations of the author of his own, discusses MDPV intoxication and withdrawal. In the metabolism of MDPV, the most important catalyst is the CYP2C19 isoenzyme, but the CYP1A2 and the CYP2D6 isoenzymes also play a crucial role. The formed catechols are conjugated with either glucuronic acid or sulfate. It is important to note that MDPV is consumed either together or in a sequence with other illicit drugs of abuse. As far as it can be established, MDPV use increases the activity and vigilance, decreases appetite and claim to sleep, but it can also provoke cardiac sensations and disturbance of perception. In the course of coming down, withdrawal after MDPV use, bone and muscle pain, hypersomnia, disturbance of vision are experienced, but panic attack may also occur. The appearance of new designer drugs on the market draws attention to a need of paradigm changing in spiritual field. Unless it happens these negative trends shall speed up.

Original languageHungarian
Pages (from-to)2010-2019
Number of pages10
JournalOrvosi Hetilap
Volume152
Issue number50
DOIs
Publication statusPublished - Dec 1 2011

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Designer Drugs
Street Drugs
Isoenzymes
Catechols
Disorders of Excessive Somnolence
Cytochrome P-450 CYP1A2
Glucuronic Acid
Cytochrome P-450 CYP2D6
Hungary
Panic Disorder
Myalgia
Appetite
pyrovalerone
Biochemistry
Sulfates
Sleep
Bone and Bones

ASJC Scopus subject areas

  • Medicine(all)

Cite this

3,4-metilén-dioxi-pirovaleron-(MDPV-) epidémia? / Kalapos, M.

In: Orvosi Hetilap, Vol. 152, No. 50, 01.12.2011, p. 2010-2019.

Research output: Contribution to journalArticle

Kalapos, M. / 3,4-metilén-dioxi-pirovaleron-(MDPV-) epidémia?. In: Orvosi Hetilap. 2011 ; Vol. 152, No. 50. pp. 2010-2019.
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