31p-15n one-bond Couplings of Diastereoisomeric Adenosine Cyclic 3‘,5’-Phosphoramidates

J. Tomasz, S. Bottka, L. Radics

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Abstract

l* J(31 P 15 N) coupling constants of Rpand Sp adenosine cyclic 31, 5 1 -phosphoramidates (1), -N-methylphosphor-amidates (2) and -N,N-dimethyIphosphoramidates (3) increase in the order of 1<2<3 and obey the Stec rule (jX^Rp)< ((Sp)). _ A possible interpretation of coupling constant differences based on differences in substituent electronegativities and variation in hybridization at nitrogen atom, is suggested.

Original languageEnglish
Pages (from-to)1297-1303
Number of pages7
JournalNucleosides and Nucleotides
Volume8
Issue number7
DOIs
Publication statusPublished - Jan 1989

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ASJC Scopus subject areas

  • Biochemistry
  • Genetics

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