3-Arylidene-1-(4-nitrophenylmethylene)-3,4-dihydro-1H-naphthalen-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells

Jonathan R. Dimmock, Umashankar Das, H. Inci Gul, Masami Kawase, Hiroshi Sakagami, Zoltán Baráth, Imre Ocsovsky, Joseph Molnár

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Abstract

The incorporation of the 1-aryl-5-(4-nitrophenyl)-3-oxo-1,4-pentadienyl group into 3,4-dihydro-1H-naphthalenyl, cyclohexyl, 2,3-dihydro-1H-indenyl and cyclopentyl scaffolds led to the discovery of various compounds with selective toxicity for malignant cells and ability to reverse multidrug resistance.

Original languageEnglish
Pages (from-to)1633-1636
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number6
DOIs
Publication statusPublished - Mar 15 2005

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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