A 2q21-qter régió trisomiája hepatoblastomában.

Translated title of the contribution: 2q21-qter trisomy in hepatoblastoma

E. Balogh, S. Swanton, C. Kiss, Z. Jakab, L. M. Secker-Walker, E. Oláh

Research output: Contribution to journalArticle

Abstract

Cytogenetic findings and fluorescens in situ hybridization results of a hepatoblastoma of a boy of two and half years of age are presented. Cytogenetic analysis and fluorescens in situ hybridization technique were performed using tumor tissue obtained by biopsy. The direct culture was harvested after 16 hour colcemid treatment. The results of G-banding were as follows: 47,XY,add(4) (q26),-9,+20. There were considerable variation in the degree of condensation and hence in the number of visible G-bands both between metaphases and between homologous chromosomes in the same metaphases. Fluorescens in situ hybridisation were carried out by whole chromosome painting probes: 2,3,4, and 20. The karyotype of the malignant cells was adjusted accordingly: 47,XY,der(4)(q35),dir ins(9;2)(p22;q?21q?25),+20. The results confirm the most common primary chromosome abnormalities in hepatoblastoma are the following: trisomy 2, trisomy 20 and 4q structural rearrangement. Fluorescens in situ hybridization confirms the importance of trisomy 2q21-qter in hepatoblastoma. Authors recommend the use of fluorescens in situ hybridization to correct any tumor karyotype with difficult or ambiguous chromosome morphology.

Original languageHungarian
Pages (from-to)3179-3183
Number of pages5
JournalOrvosi Hetilap
Volume138
Issue number50
Publication statusPublished - Dec 14 1997

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Hepatoblastoma
Trisomy
In Situ Hybridization
Metaphase
Karyotype
Chromosomes
Chromosome Painting
Demecolcine
Cytogenetic Analysis
Cytogenetics
Chromosome Aberrations
Neoplasms
Biopsy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Balogh, E., Swanton, S., Kiss, C., Jakab, Z., Secker-Walker, L. M., & Oláh, E. (1997). A 2q21-qter régió trisomiája hepatoblastomában. Orvosi Hetilap, 138(50), 3179-3183.

A 2q21-qter régió trisomiája hepatoblastomában. / Balogh, E.; Swanton, S.; Kiss, C.; Jakab, Z.; Secker-Walker, L. M.; Oláh, E.

In: Orvosi Hetilap, Vol. 138, No. 50, 14.12.1997, p. 3179-3183.

Research output: Contribution to journalArticle

Balogh, E, Swanton, S, Kiss, C, Jakab, Z, Secker-Walker, LM & Oláh, E 1997, 'A 2q21-qter régió trisomiája hepatoblastomában.', Orvosi Hetilap, vol. 138, no. 50, pp. 3179-3183.
Balogh E, Swanton S, Kiss C, Jakab Z, Secker-Walker LM, Oláh E. A 2q21-qter régió trisomiája hepatoblastomában. Orvosi Hetilap. 1997 Dec 14;138(50):3179-3183.
Balogh, E. ; Swanton, S. ; Kiss, C. ; Jakab, Z. ; Secker-Walker, L. M. ; Oláh, E. / A 2q21-qter régió trisomiája hepatoblastomában. In: Orvosi Hetilap. 1997 ; Vol. 138, No. 50. pp. 3179-3183.
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