2,3-diphosphoglycerate binding of Zn2+ and Al3+

I. Sóvágó, T. Kiss, R. Bruce Martin

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The blood red cell contains millimolar amounts of 2,3-diphosphoglycerate, yet no metal ion stability constants appear to have been determined. We show that in the free ligand the 2-phospho group is about six times more basic than the 3-phospho group. We have determined the stability constants for the binding of Zn2+ which occurs at about 0.2 mM in the red cell, and of Al3+ which reduces red cell size and inhibits haemoglobin synthesis. At physiological pH both metal ions occur predominantly as MA2 complexes. The free Zn2+ concentration permitted within the red cell by the 2:1 complex is about 0.3 μm. 2,3-Diphosphoglycerate binds Al3+ strongly enough so that at equilibrium there should be comparable concentrations of Al3+ on both sides of the red cell membrane.

Original languageEnglish
Pages (from-to)189-192
Number of pages4
JournalPolyhedron
Volume9
Issue number2-3
DOIs
Publication statusPublished - 1990

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2,3-Diphosphoglycerate
Metals
Cells
Ions
metal ions
Cell Size
Metal ions
Hemoglobins
Erythrocytes
Cell Membrane
hemoglobin
erythrocytes
Ligands
Hemoglobin
Cell membranes
ligands
Blood
synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Materials Chemistry

Cite this

2,3-diphosphoglycerate binding of Zn2+ and Al3+ . / Sóvágó, I.; Kiss, T.; Martin, R. Bruce.

In: Polyhedron, Vol. 9, No. 2-3, 1990, p. 189-192.

Research output: Contribution to journalArticle

Sóvágó, I. ; Kiss, T. ; Martin, R. Bruce. / 2,3-diphosphoglycerate binding of Zn2+ and Al3+ In: Polyhedron. 1990 ; Vol. 9, No. 2-3. pp. 189-192.
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