20-Hydroxyecdysone increases fiber size in a muscle-specific fashion in rat

Noémi Tóth, András Szabó, Péter Kacsala, Júlia Héger, Ernö Zádor

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

20-Hydroxyecdysone (20E) is an ecdysteroid hormone that regulates moulting in insects. Interestingly, 20E is also found most abundantly in plant species and has anabolic effects in vertebrates, i.e. increasing muscle size without androgen influence. The effect of 20E on slow and fast fiber types of skeletal muscle has not been reported yet. Here we present that 20E affects the size (cross-sectional area, CSA) of the different fiber types in a muscle-specific manner. The effect on fiber size was modified by the distance from the site of the treatment and the presence of a regenerating soleus muscle in the animal. Besides the fiber size, 20E also increased the myonuclear number in the fibers of normal and regenerating muscles, suggesting the activation of satellite cells. According to our results 20E may provide an alternative for substitution of anabolic-androgenic steroids in therapeutic treatments against muscle atrophy.

Original languageEnglish
Pages (from-to)691-698
Number of pages8
JournalPhytomedicine
Volume15
Issue number9
DOIs
Publication statusPublished - Sep 3 2008

Keywords

  • 20-Hydroxyecdysone
  • Muscle fiber size
  • Regeneration

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

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