2-ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrrole-1-oxide: Evaluation of the spin trapping properties

Gilles Olive, Anne Mercier, François Le Moigne, Antal Rockenbauer, Paul Tordo

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

The 2-ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrrole-l-oxide (EMPO), an easily prepared pyrroline-N-oxide has been tested as a free radical scavenger. Spin adducts of superoxide, hydroxyl radical, and other free radicals were characterized in phosphate buffer at pH 7.0 and 5.6. At pH 7 in phosphate buffer, the EMPO/O2-. spin adduct was estimated to be about five times more persistent than its DMPO analogue. Furthermore, its decay does not produce the EMPO/HO. adduct. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)403-408
Number of pages6
JournalFree Radical Biology and Medicine
Volume28
Issue number3
DOIs
Publication statusPublished - Feb 1 2000

Keywords

  • Free radicals
  • Hydroxyl radical
  • Nitrones
  • Spin trapping
  • Superoxide

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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