2′-Deoxyuridine conjugated with a reactive monobenzocyclooctyne as a DNA building block for copper-free click-type postsynthetic modification of DNA

Claudia Stubinitzky, Gergely B. Cserép, Effi Bätzner, P. Kele, Hans Achim Wagenknecht

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The carboxymethylmonobenzocyclooctyne group attached to the 5-position of a 2′-deoxyuridine in DNA allows rapid and efficient copper-free postsynthetic modification as demonstrated with a far-red emitting fluorescent azide probe. Upon labeling strong fluorescence intensity enhancement is observed.

Original languageEnglish
Pages (from-to)11218-11221
Number of pages4
JournalChemical Communications
Volume50
Issue number76
DOIs
Publication statusPublished - 2014

Fingerprint

Deoxyuridine
Azides
Fluorescent Dyes
Labeling
Copper
DNA
Fluorescence
carboxymethylmonobenzocyclooctyne

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys
  • Medicine(all)

Cite this

2′-Deoxyuridine conjugated with a reactive monobenzocyclooctyne as a DNA building block for copper-free click-type postsynthetic modification of DNA. / Stubinitzky, Claudia; Cserép, Gergely B.; Bätzner, Effi; Kele, P.; Wagenknecht, Hans Achim.

In: Chemical Communications, Vol. 50, No. 76, 2014, p. 11218-11221.

Research output: Contribution to journalArticle

Stubinitzky, Claudia ; Cserép, Gergely B. ; Bätzner, Effi ; Kele, P. ; Wagenknecht, Hans Achim. / 2′-Deoxyuridine conjugated with a reactive monobenzocyclooctyne as a DNA building block for copper-free click-type postsynthetic modification of DNA. In: Chemical Communications. 2014 ; Vol. 50, No. 76. pp. 11218-11221.
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