18F-FDG PET/CT lymphomákban: A betegség jellegébö l adódó értékelési nehézségek és összevetés az irodalmi adatokkal

Translated title of the contribution: 18F-FDG PET/CT in lymphomas: Difficulties in the evaluation of metabolism due to illness characteristics, and review of literature data

Garai Ildikó, Borbély Katalin, Barna Sándor, Szücs Bernadett, Hascsi Zsolt, Tóth Zoltán, A. Illés

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Fluor-18-deoxy-glucose (18F-FDG or FDG) positron emission tomography - computer tomography (PET/CT) has recently become integrated into the clinical routine of patients with lymphoma in Hungary. The basic condition of risk-adapted treatment of these patients is the exact staging and early objective evaluation of the effectiveness of therapy. Between 1 May 2007 and 31 October 2010, 1862 18F-FDG PET/CT examinations were conducted for lymphoma patients at the PET/CT Center in Debrecen. This is more than 15% of the total examined patient population, and this rate shows a slight increase with each year. Based on the experience obtained from lymphoma patients by routine metabolic PET/CT scans we analyzed the difficulties of the evaluation in different time frames of patients' management. It is well known that FDG uptake of lymphomas depends on multiple factors. Although most histological subtypes are associated with uptake of FDG, the intensity of the tracer uptake is different. Different intensity of FDG uptake of the same type of lymphoma following therapeutic procedures might cause difficulties in the evaluation of the scans ensuring that primary staging by PET/CT is highly required for precise measurement and reliable comparison of data. Extranodal involvement was detected in ~40% of the patients with variable rate of prevalence. Extranodal involvement is associated with great diversity and in most cases it is not characteristic of the illness and might appear in different forms and in any organs. Additionally, because accompanying disease may produce false positive results, detailed clinical data and precise case history is highly required.

Original languageHungarian
Pages (from-to)178-186
Number of pages9
JournalMagyar Onkologia
Volume55
Issue number3
Publication statusPublished - 2011

Fingerprint

Fluorodeoxyglucose F18
Positron-Emission Tomography
Lymphoma
Tomography
Hungary
Therapeutics
Glucose
Population

ASJC Scopus subject areas

  • Oncology

Cite this

18F-FDG PET/CT lymphomákban : A betegség jellegébö l adódó értékelési nehézségek és összevetés az irodalmi adatokkal. / Ildikó, Garai; Katalin, Borbély; Sándor, Barna; Bernadett, Szücs; Zsolt, Hascsi; Zoltán, Tóth; Illés, A.

In: Magyar Onkologia, Vol. 55, No. 3, 2011, p. 178-186.

Research output: Contribution to journalArticle

Ildikó, G, Katalin, B, Sándor, B, Bernadett, S, Zsolt, H, Zoltán, T & Illés, A 2011, '18F-FDG PET/CT lymphomákban: A betegség jellegébö l adódó értékelési nehézségek és összevetés az irodalmi adatokkal', Magyar Onkologia, vol. 55, no. 3, pp. 178-186.
Ildikó, Garai ; Katalin, Borbély ; Sándor, Barna ; Bernadett, Szücs ; Zsolt, Hascsi ; Zoltán, Tóth ; Illés, A. / 18F-FDG PET/CT lymphomákban : A betegség jellegébö l adódó értékelési nehézségek és összevetés az irodalmi adatokkal. In: Magyar Onkologia. 2011 ; Vol. 55, No. 3. pp. 178-186.
@article{27d46b08b35d415291043af96da643c5,
title = "18F-FDG PET/CT lymphom{\'a}kban: A betegs{\'e}g jelleg{\'e}b{\"o} l ad{\'o}d{\'o} {\'e}rt{\'e}kel{\'e}si neh{\'e}zs{\'e}gek {\'e}s {\"o}sszevet{\'e}s az irodalmi adatokkal",
abstract = "Fluor-18-deoxy-glucose (18F-FDG or FDG) positron emission tomography - computer tomography (PET/CT) has recently become integrated into the clinical routine of patients with lymphoma in Hungary. The basic condition of risk-adapted treatment of these patients is the exact staging and early objective evaluation of the effectiveness of therapy. Between 1 May 2007 and 31 October 2010, 1862 18F-FDG PET/CT examinations were conducted for lymphoma patients at the PET/CT Center in Debrecen. This is more than 15{\%} of the total examined patient population, and this rate shows a slight increase with each year. Based on the experience obtained from lymphoma patients by routine metabolic PET/CT scans we analyzed the difficulties of the evaluation in different time frames of patients' management. It is well known that FDG uptake of lymphomas depends on multiple factors. Although most histological subtypes are associated with uptake of FDG, the intensity of the tracer uptake is different. Different intensity of FDG uptake of the same type of lymphoma following therapeutic procedures might cause difficulties in the evaluation of the scans ensuring that primary staging by PET/CT is highly required for precise measurement and reliable comparison of data. Extranodal involvement was detected in ~40{\%} of the patients with variable rate of prevalence. Extranodal involvement is associated with great diversity and in most cases it is not characteristic of the illness and might appear in different forms and in any organs. Additionally, because accompanying disease may produce false positive results, detailed clinical data and precise case history is highly required.",
keywords = "Extranodal, FDG, Lymphoma, PET/CT",
author = "Garai Ildik{\'o} and Borb{\'e}ly Katalin and Barna S{\'a}ndor and Sz{\"u}cs Bernadett and Hascsi Zsolt and T{\'o}th Zolt{\'a}n and A. Ill{\'e}s",
year = "2011",
language = "Hungarian",
volume = "55",
pages = "178--186",
journal = "Magyar Onkologia",
issn = "0025-0244",
publisher = "Akademiai Kiado",
number = "3",

}

TY - JOUR

T1 - 18F-FDG PET/CT lymphomákban

T2 - A betegség jellegébö l adódó értékelési nehézségek és összevetés az irodalmi adatokkal

AU - Ildikó, Garai

AU - Katalin, Borbély

AU - Sándor, Barna

AU - Bernadett, Szücs

AU - Zsolt, Hascsi

AU - Zoltán, Tóth

AU - Illés, A.

PY - 2011

Y1 - 2011

N2 - Fluor-18-deoxy-glucose (18F-FDG or FDG) positron emission tomography - computer tomography (PET/CT) has recently become integrated into the clinical routine of patients with lymphoma in Hungary. The basic condition of risk-adapted treatment of these patients is the exact staging and early objective evaluation of the effectiveness of therapy. Between 1 May 2007 and 31 October 2010, 1862 18F-FDG PET/CT examinations were conducted for lymphoma patients at the PET/CT Center in Debrecen. This is more than 15% of the total examined patient population, and this rate shows a slight increase with each year. Based on the experience obtained from lymphoma patients by routine metabolic PET/CT scans we analyzed the difficulties of the evaluation in different time frames of patients' management. It is well known that FDG uptake of lymphomas depends on multiple factors. Although most histological subtypes are associated with uptake of FDG, the intensity of the tracer uptake is different. Different intensity of FDG uptake of the same type of lymphoma following therapeutic procedures might cause difficulties in the evaluation of the scans ensuring that primary staging by PET/CT is highly required for precise measurement and reliable comparison of data. Extranodal involvement was detected in ~40% of the patients with variable rate of prevalence. Extranodal involvement is associated with great diversity and in most cases it is not characteristic of the illness and might appear in different forms and in any organs. Additionally, because accompanying disease may produce false positive results, detailed clinical data and precise case history is highly required.

AB - Fluor-18-deoxy-glucose (18F-FDG or FDG) positron emission tomography - computer tomography (PET/CT) has recently become integrated into the clinical routine of patients with lymphoma in Hungary. The basic condition of risk-adapted treatment of these patients is the exact staging and early objective evaluation of the effectiveness of therapy. Between 1 May 2007 and 31 October 2010, 1862 18F-FDG PET/CT examinations were conducted for lymphoma patients at the PET/CT Center in Debrecen. This is more than 15% of the total examined patient population, and this rate shows a slight increase with each year. Based on the experience obtained from lymphoma patients by routine metabolic PET/CT scans we analyzed the difficulties of the evaluation in different time frames of patients' management. It is well known that FDG uptake of lymphomas depends on multiple factors. Although most histological subtypes are associated with uptake of FDG, the intensity of the tracer uptake is different. Different intensity of FDG uptake of the same type of lymphoma following therapeutic procedures might cause difficulties in the evaluation of the scans ensuring that primary staging by PET/CT is highly required for precise measurement and reliable comparison of data. Extranodal involvement was detected in ~40% of the patients with variable rate of prevalence. Extranodal involvement is associated with great diversity and in most cases it is not characteristic of the illness and might appear in different forms and in any organs. Additionally, because accompanying disease may produce false positive results, detailed clinical data and precise case history is highly required.

KW - Extranodal

KW - FDG

KW - Lymphoma

KW - PET/CT

UR - http://www.scopus.com/inward/record.url?scp=84555208668&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84555208668&partnerID=8YFLogxK

M3 - Article

C2 - 21918743

AN - SCOPUS:84555208668

VL - 55

SP - 178

EP - 186

JO - Magyar Onkologia

JF - Magyar Onkologia

SN - 0025-0244

IS - 3

ER -