17β-Estradiol increases, aging decreases, c-Fos expression in the rat accessory olfactory bulb

J. A. Balog, A. Kurunczi, A. Párducz

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In the present paper we investigated the c-Fos immunoreactivity in the accessory olfactory bulb (AOB) of juvenile, adult and old rats of both sexes, as well as the effect of 17β-estradiol on the expression of this immediate early gene. Basal c-Fos expression in the olfactory bulb decreased with age, and estrogen treatment caused an increase in the number of neurons expressing c-Fos in the AOB. The results indicate that both aging and estrogen have roles in the ability of neurons to co-ordinate genetic activity. Our observations may explain the decrease in age-related changes of brain plasticity, and provide data for the understanding of hormonally regulated neuronal plasticity.

Original languageEnglish
Pages (from-to)3787-3790
Number of pages4
JournalNeuroreport
Volume12
Issue number17
DOIs
Publication statusPublished - Dec 4 2001

Keywords

  • Accessory olfactory bulb
  • Aging
  • Estrogen
  • Immediate early genes
  • Neural plasticity
  • Sexual dimorphism

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of '17β-Estradiol increases, aging decreases, c-Fos expression in the rat accessory olfactory bulb'. Together they form a unique fingerprint.

  • Cite this