17β-Estradiol increases, aging decreases, c-Fos expression in the rat accessory olfactory bulb

J. A. Balog, A. Kurunczi, A. Párducz

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In the present paper we investigated the c-Fos immunoreactivity in the accessory olfactory bulb (AOB) of juvenile, adult and old rats of both sexes, as well as the effect of 17β-estradiol on the expression of this immediate early gene. Basal c-Fos expression in the olfactory bulb decreased with age, and estrogen treatment caused an increase in the number of neurons expressing c-Fos in the AOB. The results indicate that both aging and estrogen have roles in the ability of neurons to co-ordinate genetic activity. Our observations may explain the decrease in age-related changes of brain plasticity, and provide data for the understanding of hormonally regulated neuronal plasticity.

Original languageEnglish
Pages (from-to)3787-3790
Number of pages4
JournalNeuroReport
Volume12
Issue number17
Publication statusPublished - Dec 4 2001

Fingerprint

Olfactory Bulb
Estradiol
Estrogens
Neurons
Neuronal Plasticity
Immediate-Early Genes
Brain

Keywords

  • Accessory olfactory bulb
  • Aging
  • Estrogen
  • Immediate early genes
  • Neural plasticity
  • Sexual dimorphism

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

17β-Estradiol increases, aging decreases, c-Fos expression in the rat accessory olfactory bulb. / Balog, J. A.; Kurunczi, A.; Párducz, A.

In: NeuroReport, Vol. 12, No. 17, 04.12.2001, p. 3787-3790.

Research output: Contribution to journalArticle

@article{ec3b802b0d7c48d0b7583585bbe92358,
title = "17β-Estradiol increases, aging decreases, c-Fos expression in the rat accessory olfactory bulb",
abstract = "In the present paper we investigated the c-Fos immunoreactivity in the accessory olfactory bulb (AOB) of juvenile, adult and old rats of both sexes, as well as the effect of 17β-estradiol on the expression of this immediate early gene. Basal c-Fos expression in the olfactory bulb decreased with age, and estrogen treatment caused an increase in the number of neurons expressing c-Fos in the AOB. The results indicate that both aging and estrogen have roles in the ability of neurons to co-ordinate genetic activity. Our observations may explain the decrease in age-related changes of brain plasticity, and provide data for the understanding of hormonally regulated neuronal plasticity.",
keywords = "Accessory olfactory bulb, Aging, Estrogen, Immediate early genes, Neural plasticity, Sexual dimorphism",
author = "Balog, {J. A.} and A. Kurunczi and A. P{\'a}rducz",
year = "2001",
month = "12",
day = "4",
language = "English",
volume = "12",
pages = "3787--3790",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams and Wilkins",
number = "17",

}

TY - JOUR

T1 - 17β-Estradiol increases, aging decreases, c-Fos expression in the rat accessory olfactory bulb

AU - Balog, J. A.

AU - Kurunczi, A.

AU - Párducz, A.

PY - 2001/12/4

Y1 - 2001/12/4

N2 - In the present paper we investigated the c-Fos immunoreactivity in the accessory olfactory bulb (AOB) of juvenile, adult and old rats of both sexes, as well as the effect of 17β-estradiol on the expression of this immediate early gene. Basal c-Fos expression in the olfactory bulb decreased with age, and estrogen treatment caused an increase in the number of neurons expressing c-Fos in the AOB. The results indicate that both aging and estrogen have roles in the ability of neurons to co-ordinate genetic activity. Our observations may explain the decrease in age-related changes of brain plasticity, and provide data for the understanding of hormonally regulated neuronal plasticity.

AB - In the present paper we investigated the c-Fos immunoreactivity in the accessory olfactory bulb (AOB) of juvenile, adult and old rats of both sexes, as well as the effect of 17β-estradiol on the expression of this immediate early gene. Basal c-Fos expression in the olfactory bulb decreased with age, and estrogen treatment caused an increase in the number of neurons expressing c-Fos in the AOB. The results indicate that both aging and estrogen have roles in the ability of neurons to co-ordinate genetic activity. Our observations may explain the decrease in age-related changes of brain plasticity, and provide data for the understanding of hormonally regulated neuronal plasticity.

KW - Accessory olfactory bulb

KW - Aging

KW - Estrogen

KW - Immediate early genes

KW - Neural plasticity

KW - Sexual dimorphism

UR - http://www.scopus.com/inward/record.url?scp=0035807697&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035807697&partnerID=8YFLogxK

M3 - Article

VL - 12

SP - 3787

EP - 3790

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 17

ER -