1,6-Anhydro-1(6)-thio-l-iditol and -d-mannitol, and some derivatives thereof

János Kuszmann, P. Sohár

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Starting from 1,2:5,6-dianhydro-3,4-O-isopropylidene-l-iditol (1) and -d-mannitol (6), respectively, the corresponding 1,6-anhydro-1(6)-thio derivatives (2a and 7a) were synthesized. The discrepancy in the yields obtained, as well as the different behavior of their methylated derivatives (2e and 7c) towards acid hydrolysis, could be explained by steric factors. The di-O-mesyl derivatives 3d and 12c were unstable compounds, and showed no ulcerostatic activity, unlike the d-glucitol analog1.

Original languageEnglish
Pages (from-to)105-115
Number of pages11
JournalCarbohydrate Research
Volume56
Issue number1
DOIs
Publication statusPublished - 1977

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Sorbitol
Mannitol
Hydrolysis
Derivatives
Acids
propylene
iditol

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry

Cite this

1,6-Anhydro-1(6)-thio-l-iditol and -d-mannitol, and some derivatives thereof. / Kuszmann, János; Sohár, P.

In: Carbohydrate Research, Vol. 56, No. 1, 1977, p. 105-115.

Research output: Contribution to journalArticle

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