13. Synthesis and tritium labelling of 6β-amino-4,5α-epoxyraorphinans and their 14-hydroxy derivatives as potential affinity labelling probes with μ opioid agonist activity

F. Ötvös, Géza Tóth, Sándor Lovas, Csaba Simon, Sándor Hosztafi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The synthesis of 6β-(methylfumaramido) and 6β-chloroacetamido derivatives 1b and 1c of 6β-amino-7,8-didehydromorphinan and the corresponding 14-hydroxy derivatives 1e and 1f are described. The 7,8-dihydro derivatives of these compounds were synthesized in inactive (2b, c, e, f) as well as in tritiated form (3b, c, e, f).

Original languageEnglish
Pages (from-to)133-136
Number of pages4
JournalHelvetica Chimica Acta
Volume79
Issue number1
Publication statusPublished - 1996

Fingerprint

Tritium
tritium
Labeling
Opioid Analgesics
marking
affinity
Derivatives
probes
synthesis

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

13. Synthesis and tritium labelling of 6β-amino-4,5α-epoxyraorphinans and their 14-hydroxy derivatives as potential affinity labelling probes with μ opioid agonist activity. / Ötvös, F.; Tóth, Géza; Lovas, Sándor; Simon, Csaba; Hosztafi, Sándor.

In: Helvetica Chimica Acta, Vol. 79, No. 1, 1996, p. 133-136.

Research output: Contribution to journalArticle

@article{d9053d9a5d6640c9a58f6d322b0043c5,
title = "13. Synthesis and tritium labelling of 6β-amino-4,5α-epoxyraorphinans and their 14-hydroxy derivatives as potential affinity labelling probes with μ opioid agonist activity",
abstract = "The synthesis of 6β-(methylfumaramido) and 6β-chloroacetamido derivatives 1b and 1c of 6β-amino-7,8-didehydromorphinan and the corresponding 14-hydroxy derivatives 1e and 1f are described. The 7,8-dihydro derivatives of these compounds were synthesized in inactive (2b, c, e, f) as well as in tritiated form (3b, c, e, f).",
author = "F. {\"O}tv{\"o}s and G{\'e}za T{\'o}th and S{\'a}ndor Lovas and Csaba Simon and S{\'a}ndor Hosztafi",
year = "1996",
language = "English",
volume = "79",
pages = "133--136",
journal = "Helvetica Chimica Acta",
issn = "0018-019X",
publisher = "Verlag Helvetica Chimica Acta AG",
number = "1",

}

TY - JOUR

T1 - 13. Synthesis and tritium labelling of 6β-amino-4,5α-epoxyraorphinans and their 14-hydroxy derivatives as potential affinity labelling probes with μ opioid agonist activity

AU - Ötvös, F.

AU - Tóth, Géza

AU - Lovas, Sándor

AU - Simon, Csaba

AU - Hosztafi, Sándor

PY - 1996

Y1 - 1996

N2 - The synthesis of 6β-(methylfumaramido) and 6β-chloroacetamido derivatives 1b and 1c of 6β-amino-7,8-didehydromorphinan and the corresponding 14-hydroxy derivatives 1e and 1f are described. The 7,8-dihydro derivatives of these compounds were synthesized in inactive (2b, c, e, f) as well as in tritiated form (3b, c, e, f).

AB - The synthesis of 6β-(methylfumaramido) and 6β-chloroacetamido derivatives 1b and 1c of 6β-amino-7,8-didehydromorphinan and the corresponding 14-hydroxy derivatives 1e and 1f are described. The 7,8-dihydro derivatives of these compounds were synthesized in inactive (2b, c, e, f) as well as in tritiated form (3b, c, e, f).

UR - http://www.scopus.com/inward/record.url?scp=0041022342&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0041022342&partnerID=8YFLogxK

M3 - Article

VL - 79

SP - 133

EP - 136

JO - Helvetica Chimica Acta

JF - Helvetica Chimica Acta

SN - 0018-019X

IS - 1

ER -