1,2,3,4,5,6-Hexahydrophosphinine 1-oxides with an exocyclic P-function at position 3: Diastereoselective synthesis, stereostructure and conformation

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Abstract

Catalytic hydrogenation of the corresponding tetrahydrophosphinine oxides afforded the title compounds (4-6) as exclusive or major diastereomers the stereostructure and conformation of which were evaluated by stereospecific 3J couplings, as well as HF/6-31G* ab initio calculations.

Original languageEnglish
Pages (from-to)1655-1658
Number of pages4
JournalTetrahedron Letters
Volume46
Issue number10
DOIs
Publication statusPublished - Mar 7 2005

Keywords

  • Conformation
  • Hydrogenation
  • Phosphorus heterocycles
  • Stereoselection

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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